The Rab11Fip3 Polyclonal Antibody (PAC022538) is a valuable tool for researchers studying Rab11Fip3, a key protein involved in intracellular trafficking and vesicle transport. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in various applications, including Western blotting.Rab11Fip3 is known for its role in regulating endosomal recycling and membrane trafficking pathways, making it essential for maintaining cellular homeostasis. Dysregulation of Rab11Fip3 has been linked to various diseases, including cancer and neurodegenerative disorders, highlighting its importance in cellular function.
By targeting Rab11Fip3 with this polyclonal antibody, researchers can explore its functions in different cell types and gain insights into its involvement in disease pathogenesis. This antibody is a valuable tool for investigating the molecular mechanisms underlying intracellular transport and can contribute to the development of targeted therapies for diseases associated with Rab11Fip3 dysregulation.
Antibody Name:
RAB11FIP3 Antibody (PACO22538)
Antibody SKU:
PACO22538
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:50-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Synthesized peptide derived from C-terminal of human RAB11FIP3.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using RAB11FIP3 antibody.
Background:
Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. Also required for the structural integrity of the endosomal recycling compartment during interphase. May play a role in breast cancer cell motility by regulating actin cytoskeleton.
Synonyms:
Rab11-FIP3; EF hands-containing Rab-interacting protein; Eferin;
UniProt Protein Function:
RAB11FIP3: Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. Also required for the structural integrity of the endosomal recycling compartment during interphase. May play a role in breast cancer cell motility by regulating actin cytoskeleton. 3 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 16p13.3Cellular Component: nucleoplasm; centrosome; recycling endosome; intercellular bridge; intracellular membrane-bound organelle; recycling endosome membrane; microtubule organizing center; midbody; cytosol; endosome; cleavage furrowMolecular Function: ADP-ribosylation factor binding; protein binding; protein homodimerization activity; calcium ion binding; Rab GTPase bindingBiological Process: vesicle-mediated transport; organelle organization and biogenesis; cytokinesis; endocytic recycling
UniProt Protein Details:
NCBI Summary:
Proteins of the large Rab GTPase family (see RAB1A; MIM 179508) have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP3 is one of many proteins that interact with and regulate Rab GTPases (Hales et al., 2001 [PubMed 11495908]).[supplied by OMIM, Mar 2008]
