The RDH13 Polyclonal Antibody (PAC011787) is a valuable tool for researchers studying retinol dehydrogenase 13 (RDH13), an enzyme involved in the metabolism of vitamin A and retinoid signaling pathways. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in applications such as immunofluorescence and immunohistochemistry.RDH13 is known to play a crucial role in the oxidation of all-trans-retinol to all-trans-retinal, a key step in the conversion of vitamin A to its active form. Dysregulation of RDH13 has been implicated in various diseases, including cancer and metabolic disorders.
By targeting RDH13 with this antibody, researchers can investigate its expression and localization in different cell types and tissues, providing important insights into its function and potential therapeutic applications.Overall, the RDH13 Polyclonal Antibody is an essential tool for studying the role of RDH13 in vitamin A metabolism and retinoid signaling pathways, offering valuable information for research in areas such as cancer biology, metabolic diseases, and retinoid-related disorders.
RDH13: Does not exhibit retinol dehydrogenase (RDH) activity in vitro. Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Oxidoreductase; EC 1.1.1.-Chromosomal Location of Human Ortholog: 19q13.42Cellular Component: mitochondrial inner membrane
UniProt Protein Details:
NCBI Summary:
This gene encodes a mitochondrial short-chain dehydrogenase/reductase, which catalyzes the reduction and oxidation of retinoids. The encoded enzyme may function in retinoic acid production and may also protect the mitochondria against oxidative stress. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]
