Recombinant Human GITRL/TNFSF18 Protein (His Tag) (RPES4885)

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SKU:
RPES4885
€142

Description

ELISA Kit Technical Manual

Recombinant Human GITRL/TNFSF18 Protein (His Tag)

Background:TNFSF18 is a single-pass type II membrane protein. It is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18 cytokine binds to TNFRSF18/AITR/GITR. It regulates T-cell responses, and functions as costimulator and lower the threshold for T-cell activation and T-cell proliferation. It is Important for interactions between activated T-lymphocytes and endothelial cells and Promotes leukocyte adhesion to endothelial cells. TNFSF18 mediates activation of NF-kappa-B. As Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1. It also regulates migration of monocytes from the splenic reservoir to sites of inflammation.
Name:Recombinant Human GITRL/TNFSF18 Protein (His Tag)
Size:10µg
Assay Genie SKU:RPES4885
Synonyms:Tumor necrosis factor ligand superfamily member 18;TNFSF18;Activation-inducible TNF-related ligand;Glucocorticoid-induced TNF-related ligand;AITRL; GITRL; TL6
Species:Human
Expression host:Human Cells
Sequence:Glu74-Ser199
Accession:Q9UNG2
Mol Mass:15.3 kDa
AP Mol Mass:16 &18 kDa
Tag:C-6His
Purity:> 90 % as determined by reducing SDS-PAGE.
Endotoxin:< 1.0 EU per µg as determined by the LAL method.
Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8? for 2-7 days. Aliquots of reconstituted samples are stable at < -20'C for 3 months.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Formulation:Lyophilized from a 0.2 um filtered solution of PBS, pH7.4.
Reconstitution:Please refer to the printed manual for detailed information.
UniProt Protein Function:TNFSF18: Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T- cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Belongs to the tumor necrosis factor family.
UniProt Protein Details:

Protein type:Apoptosis; Membrane protein, integral; Cytokine

Chromosomal Location of Human Ortholog: 1q23

Cellular Component: extracellular space; cell surface; integral to membrane; plasma membrane

Molecular Function:cytokine activity; tumor necrosis factor receptor superfamily binding; tumor necrosis factor receptor binding; receptor binding

Biological Process: cell-cell signaling; tumor necrosis factor-mediated signaling pathway; T cell proliferation during immune response; regulation of T cell proliferation; signal transduction; negative regulation of apoptosis; activation of NF-kappaB transcription factor

NCBI Summary:The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells. [provided by RefSeq, Jul 2008]
UniProt Code:Q9UNG2
NCBI GenInfo Identifier:325511353
NCBI Gene ID:8995
NCBI Accession:Q9UNG2.2
UniProt Secondary Accession:Q9UNG2,O95852, Q6ISV1, A9IQG8,
UniProt Related Accession:Q9UNG2
Molecular Weight:22,724 Da
NCBI Full Name:Tumor necrosis factor ligand superfamily member 18
NCBI Synonym Full Names:tumor necrosis factor (ligand) superfamily, member 18
NCBI Official Symbol:TNFSF18  
NCBI Official Synonym Symbols:TL6; AITRL; GITRL; hGITRL  
NCBI Protein Information:tumor necrosis factor ligand superfamily member 18; AITR ligand; GITR ligand; activation-inducible TNF-related ligand; glucocorticoid-induced TNF-related ligand; glucocorticoid-induced TNFR-related protein ligand
UniProt Protein Name:Tumor necrosis factor ligand superfamily member 18
UniProt Synonym Protein Names:Activation-inducible TNF-related ligand; AITRL; Glucocorticoid-induced TNF-related ligand; hGITRL
UniProt Gene Name:TNFSF18  
UniProt Entry Name:TNF18_HUMAN
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Additional Information

Product type:
Recombinant Protein
Host species:
Human Cells
Reactivity:
Human
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