Description
Recombinant Human GITRL/TNFSF18 Protein (His Tag)
Background: | TNFSF18 is a single-pass type II membrane protein. It is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18 cytokine binds to TNFRSF18/AITR/GITR. It regulates T-cell responses, and functions as costimulator and lower the threshold for T-cell activation and T-cell proliferation. It is Important for interactions between activated T-lymphocytes and endothelial cells and Promotes leukocyte adhesion to endothelial cells. TNFSF18 mediates activation of NF-kappa-B. As Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1. It also regulates migration of monocytes from the splenic reservoir to sites of inflammation. |
Name: | Recombinant Human GITRL/TNFSF18 Protein (His Tag) |
Size: | 10µg |
Assay Genie SKU: | RPES4885 |
Synonyms: | Tumor necrosis factor ligand superfamily member 18;TNFSF18;Activation-inducible TNF-related ligand;Glucocorticoid-induced TNF-related ligand;AITRL; GITRL; TL6 |
Species: | Human |
Expression host: | Human Cells |
Sequence: | Glu74-Ser199 |
Accession: | Q9UNG2 |
Mol Mass: | 15.3 kDa |
AP Mol Mass: | 16 &18 kDa |
Tag: | C-6His |
Purity: | > 90 % as determined by reducing SDS-PAGE. |
Endotoxin: | < 1.0 EU per µg as determined by the LAL method. |
Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8? for 2-7 days. Aliquots of reconstituted samples are stable at < -20'C for 3 months. |
Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
Formulation: | Lyophilized from a 0.2 um filtered solution of PBS, pH7.4. |
Reconstitution: | Please refer to the printed manual for detailed information. |
UniProt Protein Function: | TNFSF18: Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T- cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Belongs to the tumor necrosis factor family. |
UniProt Protein Details: | Protein type:Apoptosis; Membrane protein, integral; Cytokine Chromosomal Location of Human Ortholog: 1q23 Cellular Component: extracellular space; cell surface; integral to membrane; plasma membrane Molecular Function:cytokine activity; tumor necrosis factor receptor superfamily binding; tumor necrosis factor receptor binding; receptor binding Biological Process: cell-cell signaling; tumor necrosis factor-mediated signaling pathway; T cell proliferation during immune response; regulation of T cell proliferation; signal transduction; negative regulation of apoptosis; activation of NF-kappaB transcription factor |
NCBI Summary: | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9UNG2 |
NCBI GenInfo Identifier: | 325511353 |
NCBI Gene ID: | 8995 |
NCBI Accession: | Q9UNG2.2 |
UniProt Secondary Accession: | Q9UNG2,O95852, Q6ISV1, A9IQG8, |
UniProt Related Accession: | Q9UNG2 |
Molecular Weight: | 22,724 Da |
NCBI Full Name: | Tumor necrosis factor ligand superfamily member 18 |
NCBI Synonym Full Names: | tumor necrosis factor (ligand) superfamily, member 18 |
NCBI Official Symbol: | TNFSF18 |
NCBI Official Synonym Symbols: | TL6; AITRL; GITRL; hGITRL |
NCBI Protein Information: | tumor necrosis factor ligand superfamily member 18; AITR ligand; GITR ligand; activation-inducible TNF-related ligand; glucocorticoid-induced TNF-related ligand; glucocorticoid-induced TNFR-related protein ligand |
UniProt Protein Name: | Tumor necrosis factor ligand superfamily member 18 |
UniProt Synonym Protein Names: | Activation-inducible TNF-related ligand; AITRL; Glucocorticoid-induced TNF-related ligand; hGITRL |
UniProt Gene Name: | TNFSF18 |
UniProt Entry Name: | TNF18_HUMAN |
Additional Information
Product type: |
Recombinant Protein |
Host species: |
Human Cells |
Reactivity: |
Human |