The RhAG Polyclonal Antibody (PACO01985) is a vital tool for scientists conducting research on Rh-associated glycoprotein (RhAG), a protein involved in the regulation of red blood cell production and transport of carbon dioxide in the blood. This antibody, produced in rabbits, exhibits high specificity and sensitivity for detecting RhAG in human samples, making it ideal for Western blot applications. RhAG plays a crucial role in maintaining the integrity and function of red blood cells by allowing for proper gas exchange and ensuring optimal oxygen delivery throughout the body.
Dysregulation of RhAG expression has been implicated in various blood disorders, making it a promising target for investigating hematological diseases such as anemia and hemolytic disorders.By using the RhAG Polyclonal Antibody, researchers can delve deeper into the molecular mechanisms underlying red blood cell biology and explore potential therapeutic strategies for treating conditions related to RhAG dysfunction. Its reliability and versatility make it a valuable tool for studying blood-related disorders and advancing our understanding of erythrocyte biology.
Antibody Name:
RHAG Antibody
Antibody SKU:
PACO01985
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the N-terminal region of human CD241.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
RHAG; RH50; Ammonium transporter Rh type A; Erythrocyte membrane glycoprotein Rh50; Erythrocyte plasma membrane 50 kDa glycoprotein; Rh50A; Rhesus blood group family type A glycoprotein;
UniProt Protein Function:
RHAG: Associated with rhesus blood group antigen expression. May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane. Defects in RHAG are the cause of regulator type Rh-null hemolytic anemia (RHN); also known as Rh-deficiency syndrome. RHN is a form of chronic hemolytic anemia in which the red blood cells have a stomatocytosis and spherocytosis morphology, an increased osmotic fragility, an altered ion transport system, and abnormal membrane phospholipid organization. Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC familyChromosomal Location of Human Ortholog: 6p12.3Cellular Component: integral to plasma membrane; membrane; plasma membraneMolecular Function: ammonium transmembrane transporter activity; ankyrin binding; leak channel activityBiological Process: ammonium transport; bicarbonate transport; carbon dioxide transport; cellular ion homeostasis; monovalent inorganic cation transport; nitrogen utilization; organic cation transportDisease: Overhydrated Hereditary Stomatocytosis; Rh-null, Regulator Type
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is erythrocyte-specific and is thought to be part of a membrane channel that transports ammonium and carbon dioxide across the blood cell membrane. The encoded protein appears to interact with Rh blood group antigens and Rh30 polypeptides. Defects in this gene are a cause of regulator type Rh-null hemolytic anemia (RHN), or Rh-deficiency syndrome.[provided by RefSeq, Mar 2009]
OHS; RH2; OHST; Rh50; CD241; RH50A; Rh50GP; SLC42A1Â Â
NCBI Protein Information:
ammonium transporter Rh type A
UniProt Protein Name:
Ammonium transporter Rh type A
UniProt Synonym Protein Names:
Erythrocyte membrane glycoprotein Rh50; Erythrocyte plasma membrane 50 kDa glycoprotein; Rh50A; Rhesus blood group family type A glycoprotein; Rh family type A glycoprotein; Rh type A glycoprotein; Rhesus blood group-associated ammonia channel; Rhesus blood group-associated glycoprotein; CD_antigen: CD241
