The RTTN Antibody (PAC062367) is a powerful tool for researchers studying the R2TP complex and its role in regulating cellular processes. This polyclonal antibody, generated in rabbits, specifically binds to the RTTN protein and is validated for use in immunofluorescence and immunoprecipitation applications.RTTN, also known as Rotatin, is a key player in the assembly and regulation of the R2TP complex, which is involved in various cellular functions such as protein complex assembly, protein folding, and DNA damage response. Dysregulation of the R2TP complex has been linked to diseases such as cancer and neurological disorders, making RTTN an important target for further investigation.
With the ability to detect RTTN in various cell types, this antibody is ideal for researchers in molecular biology, cell biology, and genetics who are interested in studying the mechanisms underlying cellular processes and disease development. By using the RTTN Antibody in their experiments, researchers can gain valuable insights into the intricate functions of the R2TP complex and its potential implications for therapeutic interventions.
Western Blot. Positive WB detected in: Hela whole cell lysate. All lanes: RTTN antibody at 1:1000. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 249, 68, 246, 99 kDa. Observed band size: 249 kDa.
Background:
Involved in the genetic cascade that governs left-right specification. Plays a role in the maintenance of a normal ciliary structure. Required for correct asymmetric expression of NODAL, LEFTY and PITX2.
Synonyms:
Rotatin, RTTN
UniProt Protein Function:
RTTN: Involved in the genetic cascade that governs left-right specification. Required for correct asymmetric expression of NODAL, LEFTY and PITX2. 4 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 18q22.2Cellular Component: centrosome; cytoplasmBiological Process: determination of left/right symmetryDisease: Polymicrogyria With Seizures
UniProt Protein Details:
NCBI Summary:
This gene encodes a large protein whose specific function is unknown. Absence of the orthologous protein in mouse results in embryonic lethality with deficient axial rotation, abnormal differentiation of the neural tube, and randomized looping of the heart tube during development. In human, mutations in this gene are associated with polymicrogyria with seizures. In human fibroblasts this protein localizes at the ciliary basal bodies. Given the intracellular localization of this protein and the phenotypic effects of mutations, this gene is suspected of playing a role in the maintenance of normal ciliary structure which in turn effects the developmental process of left-right organ specification, axial rotation, and perhaps notochord development. [provided by RefSeq, Jan 2013]
