The SCEL Antibody (PAC012043) is a polyclonal antibody designed for research involving the SCEL protein, a cell surface molecule implicated in skin development and hair formation. The antibody, raised in rabbits, is highly reactive with human samples and is validated for use in various applications including immunofluorescence and immunohistochemistry. It binds specifically to the SCEL protein, enabling detection and analysis in different cell types and tissue samples, making it ideal for studies in dermatology and hair biology research.
SCEL, also known as Sciellin, plays a critical role in skin barrier function and hair shaft formation by promoting cornification and keratin expression. Its significance in skin development and hair growth makes it a valuable target for research into skin disorders and hair conditions. Understanding the activity of SCEL is crucial for developing therapies that target skin and hair health, potentially leading to advancements in dermatology and cosmetology.
SCEL: May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Adaptor/scaffoldChromosomal Location of Human Ortholog: 13q22Cellular Component: cornified envelope; cytoplasmMolecular Function: protein bindingBiological Process: embryonic development; epidermis development; keratinocyte differentiation
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a precursor to the cornified envelope of terminally differentiated keratinocytes. This protein localizes to the periphery of cells and may function in the assembly or regulation of proteins in the cornified envelope. Transcript variants encoding different isoforms exist. A transcript variant utilizing an alternative polyA signal has been described in the literature, but its full-length nature has not been determined. [provided by RefSeq, Jul 2008]
