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Anti-SEPW1 Antibody (CAB15014)

SKU:
CAB15014
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
€129 - €359
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Description

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Antibody Name:Anti-SEPW1 Antibody
Antibody SKU:CAB15014
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-87 of human SEPW1 (NP_003000.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-87 of human SEPW1 (NP_003000.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MALA VRVV YCGA UGYK SKYL QLKK KLED EFPG RLDI CGEG TPQA TGFF EVMV AGKL IHSK KKGD GYVD TESK FLKL VAAI KAAL AQG
Gene ID:6415
Uniprot:P63302
Cellular Location:Cytoplasm
Calculated MW:9kDa
Observed MW:Refer to figures
Synonyms:SELENOW, SEPW1, selW
Background:This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein shows highest expression in skeletal muscle and heart, and may be involved in oxidation-reduction reactions. A retroprocessed pseudogene, SEPW1P, has been identified and mapped to chromosome 1p35-34.
UniProt Protein Function:SEPW1: Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency. Belongs to the SelWTH family. SELW subfamily.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: cytoplasm

Molecular Function:antioxidant activity; selenium binding

Biological Process: cell redox homeostasis

NCBI Summary:This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein shows highest expression in skeletal muscle and heart, and may be involved in oxidation-reduction reactions. A retroprocessed pseudogene, SEPW1P, has been identified and mapped to chromosome 1p35-34. [provided by RefSeq, Jul 2008]
UniProt Code:P63302
NCBI GenInfo Identifier:4506887
NCBI Gene ID:6415
NCBI Accession:NP_003000.1
UniProt Secondary Accession:P63302,O15532, O19096, Q86TI9, Q96KM5, A8MRR7,
UniProt Related Accession:P63302
Molecular Weight:9,448 Da
NCBI Full Name:selenoprotein W
NCBI Synonym Full Names:selenoprotein W, 1
NCBI Official Symbol:SEPW1  
NCBI Official Synonym Symbols:selW  
NCBI Protein Information:selenoprotein W
UniProt Protein Name:Selenoprotein W
Protein Family:Selenoprotein
UniProt Gene Name:SEPW1  
UniProt Entry Name:SELW_HUMAN

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