The SHC2 Polyclonal Antibody (PAC003787) is a valuable tool for researchers studying SHC2, a protein involved in intracellular signaling pathways related to cell growth and differentiation. This antibody, produced in rabbits, exhibits high specificity and sensitivity when detecting SHC2 in human samples, making it ideal for Western blot applications.SHC2, a member of the SHC (Src homology 2 domain containing) family, plays a role in transmitting signals from growth factor receptors to downstream signaling molecules, ultimately influencing cellular processes such as proliferation and survival. Dysregulation of SHC2 has been implicated in various diseases, including cancer and developmental disorders, making it a promising target for therapeutic interventions.
By utilizing the SHC2 Polyclonal Antibody, researchers can gain valuable insights into the function and regulation of SHC2 in different cell types and tissues. This antibody enables precise detection and analysis of SHC2 protein levels, facilitating studies in areas such as cell biology, cancer biology, and signal transduction pathways. Understanding the role of SHC2 in cellular signaling pathways is essential for advancing our knowledge of disease mechanisms and identifying potential therapeutic strategies.
Antibody Name:
SHC2 Antibody
Antibody SKU:
PACO03787
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human, Rat
Immunogen:
synthesized peptide derived from the Internal region of human Sck.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
SHC2; SCK; SHCB; SHC-transforming protein 2; Protein Sck; SHC-transforming protein B; Src homology 2 domain-containing-transforming protein C2; SH2 domain protein C2
UniProt Protein Function:
SHC2: an adapter protein containing an SH2 and a PID domain. Couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons and the regulation of NMDA receptor function in the hippocampus. May modulate hippocampal synaptic plasticity underlying learning and memory. Interacts with the Trk receptors in a phosphotyrosine-dependent manner. Once activated, binds to GRB2. Interacts with activated EGF receptors. Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, medulla and spinal cord. A switch from Shc1 to Shc3 occurs during maturation of neuronal precursors to postmitotic neurons. Two alternatively spliced isoforms have been described.Protein type: Adaptor/scaffoldChromosomal Location of Human Ortholog: 19p13.3Cellular Component: plasma membrane; cytosolMolecular Function: protein binding; receptor tyrosine kinase binding; protein kinase bindingBiological Process: nerve growth factor receptor signaling pathway; activation of MAPK activity; Ras protein signal transduction; insulin receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway
