Description
Anti-SLC23A2 Antibody (CAB6740)
The SLC23A2 Polyclonal Antibody (CAB6740) is specifically designed for research involving SLC23A2, a crucial cell surface molecule responsible for vitamin C transport and regulation. This antibody, produced in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blot applications. By binding to the SLC23A2 protein, it allows for accurate detection and analysis in a variety of cell types, making it an excellent tool for studies in the fields of biochemistry and molecular biology.SLC23A2, also known as the vitamin C transporter, plays a vital role in ensuring proper cellular uptake and utilization of vitamin C, a key antioxidant and essential nutrient for human health.
Research on SLC23A2 is important for understanding the mechanisms underlying vitamin C metabolism and its impact on physiological processes such as immune function, collagen synthesis, and antioxidant defense. Insights gained from studying SLC23A2 could lead to the development of novel therapies for conditions related to vitamin C deficiency and oxidative stress.
| Antibody Name: | Anti-SLC23A2 Antibody |
| Antibody SKU: | CAB6740 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human SLC23A2 (NP_976072.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:10 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SKOV3, HepG2, Mouse brain, Mouse lung, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human SLC23A2 (NP_976072.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MMGI GKNT TSKS MEAG SSTE GKYE DEAK HPAF FTLP VVIN GGAT SSGE QDNE DTEL MAIY TTEN GIAE KSSL AETL DSTG SLDP QRSD MI |
| Gene ID: | 9962 |
| Uniprot: | Q9UGH3 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 58kDa/70kDa |
| Observed MW: | 70kDa |
| Synonyms: | SLC23A2, NBTL1, SLC23A1, SVCT2, YSPL2, hSVCT2 |
| Background: | The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two required transporters and the encoded protein accounts for tissue-specific uptake of vitamin C. Previously, this gene had an official symbol of SLC23A1. |
| UniProt Protein Function: | SLC23A2: Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate. Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily. |
| UniProt Protein Details: | Protein type:Transporter; Membrane protein, integral; Transporter, SLC family; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 20p13 Cellular Component: membrane; basolateral plasma membrane; integral to plasma membrane; apical plasma membrane; cytoplasm; integral to membrane; plasma membrane; basal plasma membrane Molecular Function:L-ascorbate:sodium symporter activity; sodium-dependent multivitamin transmembrane transporter activity; L-ascorbic acid transporter activity; nucleobase transmembrane transporter activity Biological Process: vitamin metabolic process; molecular hydrogen transport; sodium ion transport; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; L-ascorbic acid metabolic process; nucleobase transport; response to oxidative stress; water-soluble vitamin metabolic process; L-ascorbic acid transport |
| NCBI Summary: | The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two required transporters and the encoded protein accounts for tissue-specific uptake of vitamin C. Previously, this gene had an official symbol of SLC23A1. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UGH3 |
| NCBI GenInfo Identifier: | 24212469 |
| NCBI Gene ID: | 9962 |
| NCBI Accession: | Q9UGH3.1 |
| UniProt Secondary Accession: | Q9UGH3,Q8WWR4, Q92512, Q96D54, Q9UNU1, Q9UP85, B4DJZ1 |
| UniProt Related Accession: | Q9UGH3 |
| Molecular Weight: | Observed MW: 70kDaCalculated MW: 58kDa/70kDa |
| NCBI Full Name: | Solute carrier family 23 member 2 |
| NCBI Synonym Full Names: | solute carrier family 23 (ascorbic acid transporter), member 2 |
| NCBI Official Symbol: | SLC23A2Â Â |
| NCBI Official Synonym Symbols: | NBTL1; SVCT2; YSPL2; SLC23A1Â Â |
| NCBI Protein Information: | solute carrier family 23 member 2; hSVCT2; yolk sac permease-like molecule 2; Na(+)/L-ascorbic acid transporter 2; nucleobase transporter-like 1 protein; sodium-dependent vitamin C transporter-2; solute carrier family 23 (nucleobase transporters), member 1; solute carrier family 23 (nucleobase transporters), member 2 |
| UniProt Protein Name: | Solute carrier family 23 member 2 |
| UniProt Synonym Protein Names: | Na(+)/L-ascorbic acid transporter 2; Nucleobase transporter-like 1 protein; Sodium-dependent vitamin C transporter 2; hSVCT2; Yolk sac permease-like molecule 2 |
| Protein Family: | Solute carrier family |
| UniProt Gene Name: | SLC23A2Â Â |
| UniProt Entry Name: | S23A2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SLC23A2 antibody (CAB6740) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of MCF7 cells using SLC23A2 antibody (CAB6740). |
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