The SRGAP2C Polyclonal Antibody (PAC046426) is a valuable tool for researchers studying SRGAP2C, a protein involved in neuronal development and synaptic plasticity. This antibody, produced in rabbits, exhibits high specificity and sensitivity in detecting SRGAP2C in human samples, making it suitable for various research applications, including Western blot analysis.SRGAP2C is a key player in neuronal development, particularly in the formation and function of synapses. By regulating the growth and remodeling of dendritic spines, SRGAP2C influences synaptic connectivity and plasticity, ultimately impacting cognitive processes and brain function.
Research on SRGAP2C is essential for understanding neurodevelopmental disorders, cognitive dysfunction, and neurological conditions.The SRGAP2C Polyclonal Antibody enables researchers to investigate the expression, localization, and function of SRGAP2C in different cell types and tissues, providing insights into its role in neuronal development and synaptic plasticity. By unraveling the mechanisms underlying SRGAP2C-mediated processes, this antibody contributes to advancements in neuroscience research and the development of potential therapeutic strategies targeting neurodevelopmental and neurological disorders.
Immunohistochemistry of paraffin-embedded human colon cancer using PACO46426 at dilution of 1:100.
Immunofluorescent analysis of A549 cells using PACO46426 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Involved in dendritic spine maturation through interaction with and inhibition of SRGAP2. Reduces the rate of spine maturation and indirectly increases neuronal migration. Changes dendritic spine morphology and density and may have implications for cognition, learning and memory.
Synonyms:
SLIT-ROBO Rho GTPase-activating protein 2C (SLIT-ROBO Rho GTPase activating protein 2 pseudogene 1), SRGAP2C, SRGAP2P1
UniProt Protein Function:
SRGAP2C: Involved in dendritic spine maturation through interaction with and inhibition of SRGAP2. Reduces the rate of spine maturation and indirectly increases neuronal migration. Changes dendritic spine morphology and density and may have implications for cognition, learning and memory. Homodimer. Interacts with SRGAP2; formation of the heterodimer alters SRGAP2 functionChromosomal Location of Human Ortholog: 1p11.2Molecular Function: protein homodimerization activity; protein heterodimerization activityBiological Process: extension of a leading process involved in cell locomotion in cerebral cortex radial glia guided migration; negative regulation of filopodium formation
UniProt Protein Details:
NCBI Summary:
This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. This human-specific locus resulted from incomplete segmental duplication of the SLIT-ROBO Rho GTPase activating protein 2 locus. The encoded protein lacks the GTPase activating protein domain compared to proteins encoded by SLIT-ROBO Rho GTPase activating protein 2. The functionality of the protein encoded by this locus has been questioned, as several normal individuals with homozygous deletions for this locus have been identified, and the expression of this locus appears to be much lower than the similar SLIT-ROBO Rho GTPase activating protein 2C (SRGAP2C) locus. The SRGAP2C locus has been shown to encode a protein that functions antagonistically to SLIT-ROBO Rho GTPase activating protein 2 in cortical neuron development. [provided by RefSeq, Dec 2012]
