The SRGAP3 Polyclonal Antibody (PAC017143) is a valuable tool for researchers studying the SRGAP3 protein, which plays a significant role in brain development and function. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. Its specificity allows for precise detection and analysis of SRGAP3 in various cell types, making it an excellent choice for studies focused on neurobiology and neurological disorders.SRGAP3, also known as Slit-Robo Rho GTPase-activating protein 3, is involved in the regulation of synaptic plasticity and dendritic spine formation, key processes in neuronal connectivity and communication.
Dysregulation of SRGAP3 has been linked to cognitive disorders and neurological conditions such as autism and schizophrenia. By studying the function of SRGAP3, researchers can gain insights into the mechanisms underlying these disorders and potentially identify new therapeutic targets for treatment.The SRGAP3 Polyclonal Antibody is an essential tool for investigating the role of SRGAP3 in brain development and disorders. Its specificity and reliability make it a valuable asset for researchers working in the field of neuroscience and neurology.
Antibody Name:
SRGAP3 Antibody (PACO17143)
Antibody SKU:
PACO17143
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Fusion protein of human SRGAP3
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO17143(SRGAP3 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).
Background:
SRGAP3 is a 1099 amino acid, protein containing 1 FCH domain, 1 Rho-GAP domain and 1 SH3 domain. Expressed highly in brain, and in lower levels in kidney, WRP is thought to play a role in cell migration through its interaction with Cdc42 and Rac1. Cdc42 and Rac1 are two intracellular signaling proteins that regulate the multistep cell migration process. WRP downregulates Cdc42 and Rac1 activity, thereby impairing actin and microtubule dynamics, the formation of protrusions, and total cell migration. Defects in the gene encoding WRP have been linked to severe idiopathic mental retardation. Three isoforms of WRP exist as a result of alternative splicing events.
Synonyms:
SLIT-ROBO Rho GTPase activating protein 3
UniProt Protein Function:
ARHGAP14: GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons. A chromosomal aberration involving SRGAP3 is found in a patient with severe idiopathic mental retardation. Translocation t(X;3)(p11.2;p25). 3 isoforms of the human protein are produced by alternative splicing.
Biological Process: regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; negative regulation of cell migration
