The STARD8 Polyclonal Antibody (PAC017162) is a valuable tool for researchers studying STARD8, a protein involved in intracellular lipid transport and metabolism. This antibody, produced in rabbits, exhibits high specificity and reactivity with human samples, making it suitable for a range of experimental applications including Western blot analysis. By targeting the STARD8 protein, researchers can investigate its role in cellular processes such as the regulation of cholesterol and lipid metabolism.STARD8, also known as StAR-related lipid transfer domain-containing protein 8, is essential for the transport of cholesterol and other lipids within cells.
Dysregulation of STARD8 has been linked to various metabolic disorders and diseases, highlighting its importance in lipid homeostasis. By studying the function of STARD8, researchers can gain insights into potential therapeutic targets for conditions such as cardiovascular disease, obesity, and diabetes.Overall, the STARD8 Polyclonal Antibody is a valuable tool for researchers interested in exploring the role of STARD8 in lipid metabolism and its implications for human health. Its high specificity and reliability make it a key asset for studies in the fields of biochemistry, cell biology, and lipid metabolism research.
Antibody Name:
STARD8 Antibody (PACO17162)
Antibody SKU:
PACO17162
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Fusion protein of human STARD8
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17162(STARD8 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene encodes a member of a subfamily of Rho GTPase activating proteins that contain a steroidogenic acute regulatory protein related lipid transfer domain. The encoded protein localizes to focal adhesions and may be involved in regulating cell morphology. This protein may also function as a tumor suppressor.
Synonyms:
StAR-related lipid transfer (START) domain containing 8
UniProt Protein Function:
STARD8: Accelerates GTPase activity of RHOA and CDC42, but not RAC1. Stimulates the hydrolysis of phosphatidylinositol 4,5- bisphosphate by PLCD1. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Protein type:GAPs, Rac/Rho; GAPs
Chromosomal Location of Human Ortholog: Xq13.1
Cellular Component: cytosol
Molecular Function:GTPase activator activity
Biological Process: regulation of small GTPase mediated signal transduction
NCBI Summary:
This gene encodes a member of a subfamily of Rho GTPase activating proteins that contain a steroidogenic acute regulatory protein related lipid transfer domain. The encoded protein localizes to focal adhesions and may be involved in regulating cell morphology. This protein may also function as a tumor suppressor. [provided by RefSeq, Mar 2010]
