The SYTL5 Polyclonal Antibody (PAC017184) is a valuable tool for researchers studying SYTL5, a protein involved in intracellular vesicle trafficking and fusion. This antibody, produced in rabbits, exhibits high specificity for SYTL5 in human samples and has been validated for use in Western blot applications. By detecting SYTL5, researchers can gain insights into how this protein regulates membrane fusion events in various cell types, making it ideal for studies in cell biology and neuroscience.SYTL5, also known as synaptotagmin-like protein 5, plays a crucial role in mediating the fusion of vesicles with target membranes, a fundamental process in cellular communication and signaling.
Dysregulation of SYTL5 has been implicated in neurological disorders and neurodegenerative diseases, highlighting the importance of studying its function in health and disease. By investigating the role of SYTL5, researchers can uncover potential therapeutic targets for conditions related to vesicle trafficking and fusion.
Antibody Name:
SYTL5 Antibody (PACO17184)
Antibody SKU:
PACO17184
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:5000, WB:1:500-1:2000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Fusion protein of human SYTL5
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Human bladder carcinoma tissue, mouse liver tissue, human fetal liver tissue, Primary antibody: PACO17184(SYTL5 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 15 seconds.
Background:
The protein encoded by this gene belongs to the synaptotagmin-like (Slp) protein family, which contains a unique homology domain at the N-terminus, referred to as the Slp homology domain (SHD). The SHD functions as a binding site for Rab27A, which plays a role in protein transport. Expression of this gene is restricted to placenta and liver, suggesting that it might be involved in Rab27A-dependent membrane trafficking in specific tissues.
Synonyms:
synaptotagmin-like 5
UniProt Protein Function:
SYTL5: May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Unknown functionChromosomal Location of Human Ortholog: Xp21.1Cellular Component: plasma membraneMolecular Function: calcium ion binding; calcium-dependent phospholipid binding; clathrin binding; protein binding; syntaxin bindingBiological Process: calcium ion-dependent exocytosis of neurotransmitter; regulation of calcium ion-dependent exocytosis; vesicle fusion
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene belongs to the synaptotagmin-like (Slp) protein family, which contains a unique homology domain at the N-terminus, referred to as the Slp homology domain (SHD). The SHD functions as a binding site for Rab27A, which plays a role in protein transport. Expression of this gene is restricted to placenta and liver, suggesting that it might be involved in Rab27A-dependent membrane trafficking in specific tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
