The TAS2R43 Monoclonal Antibody (PACO03799) is a valuable tool for researchers studying the TAS2R43 protein, a taste receptor involved in bitter taste perception. This antibody, produced using cutting-edge technology, is highly specific to TAS2R43 and is recommended for use in various applications, including immunohistochemistry and flow cytometry.TAS2R43 is a member of the TAS2R family of G protein-coupled receptors found on the surface of taste receptor cells. It plays a crucial role in detecting bitter compounds in food and beverages, triggering signaling cascades that lead to the perception of bitterness.
Studying TAS2R43 can shed light on how taste perception influences food preferences and intake, as well as how genetic variations in taste receptors impact individual taste perception.Researchers in the fields of sensory biology, nutrition, and taste science can benefit from using the TAS2R43 Monoclonal Antibody in their experiments. By targeting TAS2R43, this antibody allows for the precise detection and characterization of TAS2R43-expressing cells, facilitating a deeper understanding of bitter taste sensation and its implications for human health.
Antibody Name:
TAS2R43 Antibody
Antibody SKU:
PACO03799
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the Internal region of human T2R43.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
TAS2R43; Taste receptor type 2 member 43; T2R43; Taste receptor type 2 member 52; T2R52
UniProt Protein Function:
TAS2R43: Gustducin-coupled receptor immplicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. Activated by the sulfonyl amide sweeteners saccharin and acesulfame K. In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency. May act as chemosensory receptors in airway epithelial cells to detect and eliminate potential noxious agents from the airways. Belongs to the G-protein coupled receptor T2R family.Protein type: Membrane protein, integral; GPCR, T2R family; Membrane protein, multi-pass; Receptor, GPCRChromosomal Location of Human Ortholog: 12p13.2Cellular Component: integral to membrane; plasma membraneMolecular Function: bitter taste receptor activity; taste receptor activityBiological Process: detection of chemical stimulus involved in sensory perception of bitter taste; G-protein coupled receptor protein signaling pathway
UniProt Protein Details:
NCBI Summary:
TAS2R43 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). For further information on TAS2Rs, see MIM 604791.[supplied by OMIM, Mar 2009]
