The TENM3 Polyclonal Antibody (PACO18962) is a valuable tool for researchers studying TENM3, a cell surface protein involved in neuronal development and axon guidance. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in various applications, including Western blotting.TENM3, also known as teneurin-3, is a crucial player in the formation of neuronal circuits and synaptic connections in the brain. Its function in neuronal development makes it an important target for studies in neuroscience and neurology, with implications for understanding conditions such as autism and schizophrenia.
By detecting and analyzing the TENM3 protein in different cell types, researchers can gain insights into its role in neurodevelopmental processes. The TENM3 Polyclonal Antibody offers a reliable tool for investigating the function of this protein and its potential implications for neurological disorders.
Antibody Name:
TENM3 Antibody (PACO18962)
Antibody SKU:
PACO18962
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:5000-1:20000, IHC:1:100-1:300
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human TENM3
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO18962(TENM3 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO18962(TENM3 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This protein involved in neural development, regulating the establishment of proper connectivity within the nervous system. It promotes axon guidance and homophilic cell adhesion. And it plays a role in the development of the visual pathway; regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes.
Synonyms:
teneurin transmembrane protein 3
UniProt Protein Function:
ODZ3: May function as a cellular signal transducer. Belongs to the tenascin family. Teneurin subfamily.Protein type: Receptor, misc.; Membrane protein, integralChromosomal Location of Human Ortholog: 4q35.1Cellular Component: axon; integral to membrane; membraneMolecular Function: protein heterodimerization activity; protein homodimerization activityBiological Process: camera-type eye morphogenesis; homophilic cell adhesion; signal transductionDisease: Microphthalmia, Isolated, With Coloboma 9
UniProt Protein Details:
NCBI Summary:
This gene encodes a large transmembrane protein that may be involved in the regulation of neuronal development. Mutation in this gene causes microphthalmia. [provided by RefSeq, Aug 2015]
