Description
TGM6 Antibody (PACO20749)
The TGM6 Polyclonal Antibody (PAC020749) is a vital tool for researchers interested in studying transglutaminase 6 (TGM6), an enzyme involved in numerous biological processes including cell differentiation and apoptosis. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting TGM6 in human samples, making it an ideal choice for Western blot applications.TGM6 is known to play a crucial role in various diseases, including neurodegenerative disorders and cancer. By targeting TGM6, researchers can gain valuable insights into the mechanisms underlying these conditions and potentially identify novel therapeutic strategies.
This antibody enables researchers to explore the function of TGM6 in different cell types, paving the way for advancements in biomedicine and drug development.Overall, the TGM6 Polyclonal Antibody is a versatile tool for investigating the role of TGM6 in health and disease. Its high reactivity and specificity make it a valuable asset for researchers working in fields such as neuroscience, oncology, and cell biology. By using this antibody, scientists can uncover new pathways and potential targets for treating a variety of diseases.
| Antibody Name: | TGM6 Antibody (PACO20749) |
| Antibody SKU: | PACO20749 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human TGM6 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO20749(TGM6 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | The protein encoded by this gene belongs to the transglutaminase superfamily. It catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Mutations in this gene are associated with spinocerebellar ataxia type 35 (SCA35). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Synonyms: | transglutaminase 6 |
| UniProt Protein Function: | TGM6: an enzyme of the transglutaminase family that catalyzes the crosslinking of proteins and the conjugation of polyamines to proteins. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. Two alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Transferase; EC 2.3.2.13 Chromosomal Location of Human Ortholog: 20p13 Cellular Component: cytoplasm Molecular Function:protein-glutamine gamma-glutamyltransferase activity; metal ion binding Biological Process: peptide cross-linking Disease: Spinocerebellar Ataxia 35 |
| NCBI Summary: | The protein encoded by this gene belongs to the transglutaminase superfamily. It catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Mutations in this gene are associated with spinocerebellar ataxia type 35 (SCA35). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] |
| UniProt Code: | O95932 |
| NCBI GenInfo Identifier: | 119631005 |
| NCBI Gene ID: | 343641 |
| NCBI Accession: | EAX10600.1 |
| UniProt Secondary Accession: | O95932,Q5JXU4, Q5JXU5, Q719M2, Q719M3, Q9Y4U8, |
| UniProt Related Accession: | O95932 |
| Molecular Weight: | 70,516 Da |
| NCBI Full Name: | transglutaminase 6, partial |
| NCBI Synonym Full Names: | transglutaminase 6 |
| NCBI Official Symbol: | TGM6Â Â |
| NCBI Official Synonym Symbols: | TG6; TGY; SCA35; TGM3L; dJ734P14.3Â Â |
| NCBI Protein Information: | protein-glutamine gamma-glutamyltransferase 6 |
| UniProt Protein Name: | Protein-glutamine gamma-glutamyltransferase 6 |
| UniProt Synonym Protein Names: | Transglutaminase Y; TGY; TGase Y; Transglutaminase-3-like; TGase-3-like; Transglutaminase-6; TG6; TGase-6 |
| Protein Family: | Protein-glutamine gamma-glutamyltransferase |
| UniProt Gene Name: | TGM6Â Â |
| UniProt Entry Name: | TGM3L_HUMAN |
