The THAP4 Polyclonal Antibody (PAC017231) is a valuable tool for researchers studying THAP4, a transcription factor involved in various cellular processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding to the THAP4 protein, this antibody enables the detection and analysis of THAP4 in different cell types, making it ideal for investigations in molecular biology and gene regulation studies.
THAP4 is known to play a role in gene transcription, cell cycle regulation, and DNA damage response. Its involvement in these fundamental cellular processes makes it a potential target for research in fields such as cancer biology, developmental biology, and neurodegenerative diseases. Understanding the function of THAP4 could lead to insights into its mechanisms of action and potential therapeutic interventions in related disorders.
Antibody Name:
THAP4 Antibody (PACO17231)
Antibody SKU:
PACO17231
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Fusion protein of human THAP4
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO17231(THAP4 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
Background:
Human THAP4 is a 577 residue protein of unknown function that is proposed to bind DNA in a sequence specific manner similar to THAP1 and has been found to be upregulated in response to heat shock.THAP4 is expressed in a relatively uniform manner in a broad range of tissues and appears to be upregulated in lymphoma cells and highly expressed in heart cells13. The C-terminal domain of THAP4 (residues 415-577), designated here as cTHAP4, is evolutionarily conserved and is observed in all know THAP4 orthologues. Several single domain proteins lacking a THAP domain are found in plants and bacteria, and show significant levels of homology to cTHAP4. It appears that cTHAP4 belongs to a large class of proteins that have yet to be fully functionally characterized.
