The TMBIM4 Polyclonal Antibody (PACO4561) is a powerful tool for researchers studying TMBIM4, a protein involved in regulating cell survival, apoptosis, and calcium homeostasis. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it well-suited for use in Western blotting applications. By binding to the TMBIM4 protein, this antibody enables researchers to detect and analyze TMBIM4 expression in various cell types, making it an essential tool for studies in cell biology and cancer research.
TMBIM4, also known as BAX-inhibitor 1, plays a crucial role in protecting cells from apoptosis and maintaining cellular integrity. Its involvement in calcium signaling and apoptosis regulation makes it a key player in cell survival pathways and a potential target for therapeutic interventions in diseases such as cancer and neurodegenerative disorders. Understanding the function of TMBIM4 is essential for developing strategies to modulate cell fate and potentially treat diseases characterized by dysregulated cell death pathways.
Antibody Name:
TMBIM4 Antibody
Antibody SKU:
PACO04561
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human, Rat
Immunogen:
synthesized peptide derived from the Internal region of human GAAP.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
TMBIM4; GAAP; LFG4; CGI-119; Protein lifeguard 4; Golgi anti-apoptotic protein; Protein S1R; Transmembrane BAX inhibitor motif-containing protein 4; Z-protein
UniProt Protein Function:
TMBIM4: Anti-apoptotic protein which can inhibit apoptosis induced by intrinsic and extrinsic apoptotic stimuli. Can modulate both capacitative Ca2+ entry and inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ release. Belongs to the BI1 family. LFG subfamily.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 12q14.3Cellular Component: Golgi membrane; Golgi stack; integral to membraneMolecular Function: protein bindingBiological Process: apoptosis; negative regulation of apoptosis; regulation of calcium-mediated signaling
