The TMC8 Antibody (PACO02507) is a high-quality polyclonal antibody designed for use in research involving TMC8, a protein associated with immunodeficiency disorders. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. It specifically targets the TMC8 protein, allowing for precise detection and analysis in a variety of cell types.TMC8, also known as EVER2, plays a crucial role in immune function by helping to regulate the skin's defense against viral infections. Mutations in the TMC8 gene have been linked to severe skin conditions and susceptibility to certain viral infections.
Research into the function and expression of TMC8 is essential for understanding the mechanisms underlying these disorders and developing potential therapeutic interventions.By utilizing the TMC8 Antibody in your experiments, you can gain valuable insights into the role of TMC8 in immune responses and viral defense mechanisms. This antibody is an invaluable tool for researchers studying immunodeficiency disorders, viral infections, and skin diseases, providing important data to advance our understanding of these complex conditions.
Antibody Name:
TMC8 Antibody
Antibody SKU:
PACO02507
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the C-terminal region of human TMC8.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
TMC8; EVER2; EVIN2; Transmembrane channel-like protein 8; Epidermodysplasia verruciformis protein 2
UniProt Protein Function:
TMC8: an endoplasmic reticulum multipass membrane protein. Defects in TMC8 cause Lutz-Lewandowsky epidermodysplasia verruciformis [MIM:226400], a rare skin disease characterized by increased susceptibility to infection by papillomaviruses with an accompanying high risk of skin carcinoma. Three splice-variant isoforms of the human protein have been described.Protein type: Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 17q25.3Cellular Component: cytoplasm; endoplasmic reticulum; extracellular space; Golgi apparatus; nuclear membraneMolecular Function: protein binding; receptor bindingBiological Process: negative regulation of protein binding; negative regulation of protein oligomerization; regulation of cell growth; zinc ion homeostasisDisease: Epidermodysplasia Verruciformis
UniProt Protein Details:
NCBI Summary:
Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs. [provided by RefSeq, Jul 2008]
