The TRIM40 Polyclonal Antibody (PACO20360) is a valuable tool for researchers studying the TRIM40 protein, a member of the tripartite motif (TRIM) family implicated in immune signaling and regulation. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is specifically validated for use in Western blot applications. By targeting the TRIM40 protein, researchers can detect and analyze its expression in various cell types, offering insights into its role in immunology and potential applications in cancer research.
TRIM40 has been identified as a key player in immune response modulation, with implications in inflammatory diseases and cancer progression. Its ability to regulate immune signaling pathways makes it a promising target for further investigation and potential therapeutic development. By utilizing the TRIM40 Polyclonal Antibody, researchers can deepen their understanding of this protein's function and its impact on immune system function in health and disease.
Gel: 8%SDS-PAGE, Lysate: 40 µg, Lane: Human normal stomach tissue, Primary antibody: PACO20360(TRIM40 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20360(TRIM40 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a member of the tripartite motif (TRIM) protein family. The encoded protein may play a role as a negative regulator against inflammation and carcinogenesis in the gastrointestinal tract. Alternatively spliced transcript variants that encode different protein isoforms have been described.
Synonyms:
tripartite motif containing 40
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a RING-type E3 ubiquitin ligase and is predicted to contain a transmembrane domain, a protease-associated domain, an ectodomain, and a cytoplasmic RING domain. This protein is thought to negatively regulate Wnt signaling, and expression of this gene results in an increase in ubiquitination of frizzled receptors, an alteration in their subcellular distribution, resulting in reduced surface levels of these receptors. Mutations in this gene have been reported in multiple tumor cells, including colorectal and endometrial cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]
