The Trim68 Antibody (PACO01800) is a valuable tool for researchers studying the Trim68 protein, a member of the tripartite motif (TRIM) family involved in various cellular processes. This polyclonal antibody, produced in rabbits, has high reactivity with human samples and is validated for use in Western blot applications, allowing for the detection and analysis of Trim68 protein levels in different cell types.Trim68 is known to play a role in diverse biological functions, including transcriptional regulation, cell proliferation, and immune response.
Its involvement in these processes makes it a target of interest for research on various diseases, such as cancer, viral infections, and autoimmune disorders. By studying Trim68 with this antibody, researchers can gain insights into its function and potential therapeutic applications in these conditions.
Antibody Name:
TRIM68 Antibody
Antibody SKU:
PACO01800
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the Internal region of human SS-56.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
TRIM68; GC109; RNF137; SS56; E3 ubiquitin-protein ligase TRIM68; RING finger protein 137; SSA protein SS-56; SS-56; Tripartite motif-containing protein 68
UniProt Protein Function:
TRIM68: Functions as an ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity. Belongs to the TRIM/RBCC family.Protein type: EC 6.3.2.-; Ubiquitin conjugating systemChromosomal Location of Human Ortholog: 11p15.4Cellular Component: cytoplasm; cytosol; Golgi apparatus; nucleolus; nucleusMolecular Function: androgen receptor binding; histone acetyltransferase binding; ubiquitin-protein ligase activityBiological Process: protein autoubiquitination
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the tripartite motif-containing protein family, whose members are characterized by a "really interesting new gene" (RING) finger domain, a zinc-binding B-box motif, and a coiled-coil region. Members of this family function as E3 ubiquitin ligases and are involved in a broad range of biological processes. This gene regulates the activation of nuclear receptors, such as androgen receptor, and has been implicated in development of prostate cancer cells, where its expression increases in response to a downregulation of microRNAs. In addition, this gene participates in viral defense regulation as a negative regulator of interferon-beta. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
