The TRIM74 Polyclonal Antibody (PAC017315) is a valuable tool for research involving TRIM74, a protein implicated in cellular processes such as immune response and inflammation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the TRIM74 protein, this antibody enables researchers to detect and analyze TRIM74 expression in various cell types, making it suitable for studies in immunology and cancer research.TRIM74, also known as a member of the tripartite motif (TRIM) protein family, plays a crucial role in modulating immune response and inflammatory pathways.
Its involvement in these processes highlights its potential as a therapeutic target for diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. By investigating the function of TRIM74, researchers can gain insights that may lead to the development of novel treatment approaches that manipulate immune responses in disease settings.
Antibody Name:
TRIM74 Antibody (PACO17315)
Antibody SKU:
PACO17315
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:30-1:150
Species Reactivity:
Human
Immunogen:
Full length fusion protein
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO17315(TRIM74 Antibody) at dilution 1/45, on the right is treated with fusion protein. (Original magnification: x200).
Background:
TRIM 74 (Tripartite motif-containing protein 74) is a possible protein coding regions found at gene location 7q11.23. Tripartite motif (TRIM) proteins play important roles in a variety of cellular functions including cell proliferation, differentiation, development, oncogenesis, and apoptosis. TRIM gene expression analysis in primary human immune cells seem to suggest the involvement of TRIM proteins in also regulating host antiviral activities. The gene encoding TRIM 74 maps to human chromosome 7, which houses over 1,000 genes and comprises nearly 5% of the human genome. Chromosome 7 has been linked to Osteogenesis imperfecta, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome. The deletion of a portion of the q arm of chromosome 7 is associated with Williams-Beuren syndrome, a condition characterized by mild mental retardation, an unusual comfort and friendliness with strangers and an elfin appearance. Deletions of portions of the q arm of chromosome 7 are also seen in a number of myeloid disorders including cases of acute myelogenous leukemia and myelodysplasia.
Synonyms:
tripartite motif containing 74
UniProt Protein Function:
TRIM74: Belongs to the TRIM/RBCC family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Ubiquitin conjugating systemChromosomal Location of Human Ortholog: 7q11.23
