The VPS26A Polyclonal Antibody (CAB14265) is a valuable tool for researchers studying the VPS26A protein. This polyclonal antibody is raised in rabbits and is highly reactive with human samples, making it suitable for experiments involving VPS26A in Western blot applications.VPS26A is a key component of the retromer complex, which plays a crucial role in the recycling of transmembrane proteins from endosomes to the trans-Golgi network. Dysregulation of VPS26A has been linked to various diseases, including neurodegenerative disorders and cancer. Therefore, studying the function of VPS26A using this polyclonal antibody can provide insights into the mechanisms underlying these diseases.
Researchers in the fields of cell biology, neuroscience, and cancer research can benefit from the use of the VPS26A Polyclonal Antibody (CAB14265) to investigate the role of VPS26A in cellular processes and disease pathogenesis. This antibody enables the detection and analysis of VPS26A in various cell types, making it a versatile tool for understanding the function of this protein in different biological contexts.
Product Name:
VPS26A Rabbit Polyclonal Antibody
SKU:
CAB14265
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 256-327 of human VPS26A (NP_004887.2).
Cytoplasm, Early endosome, Endosome membrane, Peripheral membrane protein.
Calculated MW:
38kDa
Observed MW:
40kDa
This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
9559
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using VPS26A antibody (CAB14265) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
