The VPS41 Polyclonal Antibody (PACO17435) is a powerful tool for researchers studying the VPS41 protein, which plays a crucial role in intracellular trafficking and organelle function. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding to the VPS41 protein, researchers can detect and analyze its expression in various cell types, making this antibody ideal for investigations in cell biology and disease research.VPS41 is a key component of the VPS-C complex, essential for vesicle trafficking and protein sorting within cells.
Dysregulation of VPS41 has been linked to various diseases, including neurological disorders and lysosomal storage disorders. Studying the function and localization of VPS41 with this antibody can provide valuable insights into these pathologies, as well as potential therapeutic targets for intervention. Unlocking the mechanisms of VPS41 action is critical for advancing our understanding of cellular processes and disease development.
Antibody Name:
VPS41 Antibody (PACO17435)
Antibody SKU:
PACO17435
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Fusion protein of human VPS41
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO17435(VPS41 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17435(VPS41 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).
Background:
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human ortholog of yeast Vps41 protein which is also conserved in Drosophila, tomato, and Arabidopsis. Expression studies in yeast and human indicate that this protein may be involved in the formation and fusion of transport vesicles from the Golgi. Several transcript variants encoding different isoforms have been described for this gene, however, the full-length nature of not all is known.
Synonyms:
vacuolar protein sorting 41 homolog (S. cerevisiae)
UniProt Protein Function:
VPS41: Required for vacuolar assembly and vacuolar traffic. Belongs to the VPS41 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Ubiquitin conjugating system; VesicleChromosomal Location of Human Ortholog: 7p14-p13Cellular Component: clathrin-coated vesicle; endosome membrane; late endosome membrane; lysosomal membraneMolecular Function: GTPase binding; identical protein binding; protein bindingBiological Process: endosomal vesicle fusion; endosome to lysosome transport; protein targeting to vacuole; vacuole fusion, non-autophagic
UniProt Protein Details:
NCBI Summary:
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human ortholog of yeast Vps41 protein which is also conserved in Drosophila, tomato, and Arabidopsis. Expression studies in yeast and human indicate that this protein may be involved in the formation and fusion of transport vesicles from the Golgi. Several transcript variants encoding different isoforms have been described for this gene, however, the full-length nature of not all is known. [provided by RefSeq, Jul 2008]
