WDR45B Antibody (PACO20876)
- SKU:
- PACO20876
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
WDR45B Antibody (PACO20876)
The WDR45B Polyclonal Antibody (PAC020876) is a valuable tool for researchers studying the WDR45B protein, a key player in autophagy and lysosomal function. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to WDR45B, the antibody allows for precise detection and analysis of the protein in various cell types, making it an essential component for studies in cellular biology and disease mechanisms.WDR45B, also known as WIPI4, is involved in autophagosome formation and autophagy flux, processes essential for cellular homeostasis and clearance of damaged organelles and proteins.
Dysregulation of autophagy has been linked to various diseases, including neurodegenerative disorders and cancer, highlighting the importance of studying proteins like WDR45B to better understand these conditions. By investigating the function of WDR45B, researchers can uncover potential therapeutic targets and strategies for treating autophagy-related diseases.
| Antibody Name: | WDR45B Antibody (PACO20876) |
| Antibody SKU: | PACO20876 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:30-1:150 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human WDR45B |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20876(WDR45B Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | This gene encodes a member of the WIPI or SVP1 family of WD40 repeat-containing proteins. The protein contains seven WD40 repeats that are thought to fold into a beta-propeller structure that mediates protein-protein interactions, and a conserved motif for interaction with phospholipids. The human genome contains several pseudogenes of this gene. |
| Synonyms: | WD repeat domain 45B |
| UniProt Protein Function: | WDR45B: an ubiquitously expressed WD40 repeat protein. Up-regulated in a variety of tumor tissues including ovarian and uterine cancers. WD40 repeats are found in a number of eukaryotic proteins that coordinate multi-protein complex assemblies. WD40 proteins are implicated in many functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly.Protein type: Adaptor/scaffoldChromosomal Location of Human Ortholog: 17q25.3Cellular Component: extrinsic to membrane; pre-autophagosomal structure membrane; cytosolMolecular Function: phosphatidylinositol 3-phosphate bindingBiological Process: protein amino acid lipidation; mitochondrion degradation; autophagic vacuole formation; cellular response to nitrogen starvation |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the WIPI or SVP1 family of WD40 repeat-containing proteins. The protein contains seven WD40 repeats that are thought to fold into a beta-propeller structure that mediates protein-protein interactions, and a conserved motif for interaction with phospholipids. The human genome contains several pseudogenes of this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q5MNZ6 |
| NCBI GenInfo Identifier: | 85542094 |
| NCBI Gene ID: | 56270 |
| NCBI Accession: | Q5MNZ6.2 |
| UniProt Secondary Accession: | Q5MNZ6,O95328, Q2MCP6, Q6IBN2 |
| UniProt Related Accession: | Q5MNZ6 |
| Molecular Weight: | 38,122 Da |
| NCBI Full Name: | WD repeat domain phosphoinositide-interacting protein 3 |
| NCBI Synonym Full Names: | WD repeat domain 45B |
| NCBI Official Symbol: | WDR45B |
| NCBI Official Synonym Symbols: | WIPI3; WDR45L; WIPI-3 |
| NCBI Protein Information: | WD repeat domain phosphoinositide-interacting protein 3; WDR45-like protein; WIPI49-like protein; WD repeat protein 45-like; WD repeat-containing protein 45B; WD repeat-containing protein 45-like |
| UniProt Protein Name: | WD repeat domain phosphoinositide-interacting protein 3 |
| UniProt Synonym Protein Names: | WD repeat-containing protein 45-like; WDR45-like protein; WD repeat-containing protein 45B; WIPI49-like protein |
| Protein Family: | |
| UniProt Gene Name: | WDR45B |
| UniProt Entry Name: | WIPI3_HUMAN |
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