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ALOX5 Cell-Based ELISA

Product Description: The ALOX5 Colorimetric Cell-Based ELISA Kit allows for qualitative detection of ALOX5 in plated and fixed cells.
Target Synonyms: 5-lipoxygenase; ALOX5; Arachidonate 5-lipoxygenase; LOG5; LOX5
Detection Target: Phospho-IRAK1(Thr209)
Reactivity: H, M, R
Pack Size: 1 x 96 assays
Detection Method: Colorimetric 450 nm
Format: Cell-Based ELISA
Storage and Stability Guarantee: 4°C/6 Months
Sample Type: Plated & fixed cells
Range: 5000 cells/well minimum
Time: 4.5 hours

ALOX5 Cell-Based ELISA Protein Information

UniProt Protein Function:5-LO: arachidonate 5-lipoxygenase. Arachidonic acid promotes its phosphorylation by p38 MAPK-regulated MAPKAP kinases. Upregulated in glioblastoma multiforme and colon, pancreatic and bladder cancer.
UniProt Protein Details:

Protein type:Lipid Metabolism - linoleic acid; Nuclear envelope; EC; Oxidoreductase; Lipid Metabolism - arachidonic acid

Chromosomal Location of Human Ortholog: 10q11.2

Cellular Component: extracellular space; nuclear membrane; nuclear matrix; nuclear envelope lumen; nuclear envelope; cytosol

Molecular Function:protein binding; iron ion binding; arachidonate 5-lipoxygenase activity

Biological Process: leukotriene biosynthetic process; leukotriene production during acute inflammatory response; lipoxygenase pathway; arachidonic acid metabolic process; leukotriene metabolic process

Disease: Asthma, Susceptibility To

NCBI Summary:This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
UniProt Code:P09917
NCBI GenInfo Identifier:126407
NCBI Gene ID:240
NCBI Accession:P09917.2
UniProt Secondary Accession:P09917,Q5JQ14, B7ZLS0, E5FPY5, E5FPY7, E5FPY8,
UniProt Related Accession:P09917
Molecular Weight:674
NCBI Full Name:Arachidonate 5-lipoxygenase
NCBI Synonym Full Names:arachidonate 5-lipoxygenase
NCBI Official Symbol:ALOX5
NCBI Official Synonym Symbols:5-LO; 5LPG; LOG5; 5-LOX
NCBI Protein Information:arachidonate 5-lipoxygenase; LOX-5; leukotriene A4 synthase; arachidonic acid 5-lipoxygenase; arachidonic 5-lipoxygenase alpha-10 isoform; arachidonic 5-lipoxygenase delta-13 isoform; arachidonic 5-lipoxygenase delta-p10 isoform; arachidonic 5-lipoxygenase delta-10-13 isoform
UniProt Protein Name:Arachidonate 5-lipoxygenase
Protein Family:Arachidonate 5-lipoxygenase
UniProt Gene Name:ALOX5
UniProt Entry Name:LOX5_HUMAN