Anti-Mouse CD122 (IL-2Rβ) In Vivo Antibody

Product Name:	Anti-Mouse CD122 (IL-2Rβ) In Vivo Antibody - Low Endotoxin
Product Code:	IVMB0315
Size:	0.5 mg, 1 mg, 5 mg
Clone:	TM-β1
Protein:	CD122
Product Type:	Monoclonal Antibody
Synonyms:	IL-2Rβ, Interleukin 2 receptor β chain, IL-2/15Rb
Isotype:	IgG2b k
Reactivity:	Mouse
Applications:	B, Depletion, FC, In Vivo, IP, WB
Formulation:	This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Endotoxin Level:	< 1.0 EU/mg as determined by the LAL method
Purity:	≥95% monomer by analytical SEC ⋅ >95% by SDS Page
Product Preparation:	Functional grade preclinical antibodies are manufactured in an animal free facility using in vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.

Applications:	B, Depletion, FC, In Vivo, IP, WB
Reactivity:	Mouse

Host Species:	Rat
Specificity:	Clone TM-β1 recognizes an epitope on mouse CD122.
Antigen Distribution:	CD122 is expressed on NK cells and at lower levels by T lymphocytes, B lymphocytes, monocytes, and macrophages.
Immunogen:	Rat T-cell line expressing Mouse IL-2Rβ
Concentration:	≥ 5.0 mg/ml
Endotoxin Level:	< 1.0 EU/mg as determined by the LAL method
Formulation:	This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Purity:	≥95% monomer by analytical SEC ⋅ >95% by SDS Page
Preparation:	Functional grade preclinical antibodies are manufactured in an animal free facility using in vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling:	Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

CD122 is a 70-75 kD IL-2 receptor β chain that is a type I membrane protein. CD122 is involved in T cell-mediated immune responses and its activation increases proliferation of CD8+ effector T cells. It exists in three forms with varying degrees of binding affinity with IL-2. The low affinity form is a monomer of the α subunit and has no involvement in signal transduction. The intermediate affinity form is a gamma/β heterodimer and the high affinity form is an α/β/gamma heterotrimer. The intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. This protein also interacts with the IL-15 receptor.

Protein:	CD122
Function:	Critical component of IL-2 and IL-15 signaling
Ligand/Receptor:	IL-2, IL-15
Research Area:	Immunology
Shipping:	2-8°C
PubMed:	CD122
NCBI Gene Bank ID:	16185
UniProt:	CD122