The SLC38A1 Polyclonal Antibody (CAB20717) is a valuable tool for researchers studying SLC38A1, a crucial transporter protein involved in the regulation of amino acid metabolism and cellular nutrient uptake. This antibody, generated in rabbits, exhibits high specificity and reactivity with human samples, making it an excellent choice for Western blot applications.SLC38A1, also known as sodium-coupled neutral amino acid transporter 1, plays a key role in the transport of essential amino acids across cell membranes, influencing cell growth, proliferation, and metabolism. Dysregulation of SLC38A1 expression or function has been linked to various diseases, including cancer, metabolic disorders, and neurological conditions.
By using the SLC38A1 Polyclonal Antibody, researchers can detect and study the expression levels and localization of SLC38A1 in different cell types and tissues, providing valuable insights into its role in cellular physiology and disease pathology. This antibody is a valuable tool for investigations in the fields of biochemistry, cell biology, and molecular biology, with potential implications for the development of targeted therapies in various disease contexts.
Product Name:
SLC38A1 Polyclonal Antibody
SKU:
CAB20717
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human SLC38A1 (NP_001070952.1).
basolateral plasma membrane, external side of apical plasma membrane, extracellular exosome, plasma membrane
Calculated MW:
54kDa
Observed MW:
50-70kDa
Amino acid transporters play essential roles in the uptake of nutrients, production of energy, chemical metabolism, detoxification, and neurotransmitter cycling. SLC38A1 is an important transporter of glutamine, an intermediate in the detoxification of ammonia and the production of urea. Glutamine serves as a precursor for the synaptic transmitter, glutamate (Gu et al., 2001 [PubMed 11325958]).
Purification Method:
Affinity purification
Gene ID:
81539
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SLC38A1 Rabbit pAb (CAB20717) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 60s.
