Human ALDOA Recombinant Protein (RPPB1391)
- SKU:
- RPPB1391
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P04075
- Research Area:
- Enzymes
Description
| Product Name: | Human ALDOA Recombinant Protein |
| Product Code: | RPPB1391 |
| Size: | 20µg |
| Species: | Human |
| Target: | ALDOA |
| Synonyms: | Fructose-bisphosphate aldolase A, Muscle-type aldolase, Lung cancer antigen NY-LU-1, ALDOA, ALDA, EC 4.1.2.13, GSD12, MGC10942, MGC17716, MGC17767, Aldolase-A. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear colorless solution. |
| Formulation: | The ALDOA solution contains 20mM Tris-HCl pH-8, 0.1M NaCl and 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MPYQYPALTP EQKKELSDIA HRIVAPGKGI LAADESTGSI AKRLQSIGTE NTEENRRFYR QLLLTADDRV NPCIGGVILF HETLYQKADD GRPFPQVIKS KGGVVGIKVD KGVVPLAGTN GETTTQGLDG LSERCAQYKK DGADFAKWRC VLKIGEHTPS ALAIMENANV LARYASICQQ NGIVPIVEPE ILPDGDHDLK RCQYVTEKVL AAVYKALSDH HIYLEGTLLK PNMVTPGHAC TQKFSHEEIA MATVTALRRT VPPAVTGITF LSGGQSEEEA SINLNAINKC PLLKPWALTF SYGRALQASA LKAWGGKKEN LKAAQEEYVK RALANSLACQ GKYTPSGQAG AAASESLFVS NHAY |
Aldolase A (ALDOA) is a glycolytic enzyme, which catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. ALDOA is found in the developing embryo and is produced in even greater amounts in adult muscle. ALDOA expression is repressed in the adult liver, kidney and intestine and similar to ALDOC levels in the brain and other nervous tissue. ALDOA deficiency has been linked with myopathy and hemolytic anemia.
ALDOA Human Recombinant fused to 20 amino acid His Tag at N-terminal produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 384 amino acids (1-364 a.a.) and having a molecular mass of 41.5 kDa. The ALDOA is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | ALDOA: a glycolytic enzyme that catalyzes D-fructose 1,6-bisphosphate -> glycerone phosphate + D-glyceraldehyde 3-phosphate. Three forms of aldolase are found in vertebrates - aldolase A in muscle, aldolase B in liver and aldolase C in brain. |
| UniProt Protein Details: | Protein type:Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 4.1.2.13; Carbohydrate Metabolism - fructose and mannose; Lyase; Carbohydrate Metabolism - pentose phosphate pathway; Mitochondrial Chromosomal Location of Human Ortholog: 16p11.2 Cellular Component: I band; extracellular space; membrane; extracellular region; M band; cytosol; nucleus; actin cytoskeleton Molecular Function:tubulin binding; identical protein binding; protein binding; cytoskeletal protein binding; fructose-bisphosphate aldolase activity; actin binding Biological Process: platelet activation; striated muscle contraction; glycolysis; glucose metabolic process; actin filament organization; pathogenesis; protein homotetramerization; gluconeogenesis; muscle maintenance; regulation of cell shape; fructose 1,6-bisphosphate metabolic process; platelet degranulation; ATP biosynthetic process; carbohydrate metabolic process; blood coagulation; fructose metabolic process Disease: Glycogen Storage Disease Xii |
| NCBI Summary: | The protein encoded by this gene, Aldolase A (fructose-bisphosphate aldolase), is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle. Aldolase A expression is repressed in adult liver, kidney and intestine and similar to aldolase C levels in brain and other nervous tissue. Aldolase A deficiency has been associated with myopathy and hemolytic anemia. Alternative splicing and alternative promoter usage results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 3 and 10. [provided by RefSeq, Aug 2011] |
| UniProt Code: | P04075 |
| NCBI GenInfo Identifier: | 113606 |
| NCBI Gene ID: | 226 |
| NCBI Accession: | P04075.2 |
| UniProt Secondary Accession: | P04075,Q6FH76, Q6FI10, Q96B15, Q9BWD9, Q9UCN2, B4DXI7 |
| UniProt Related Accession: | P04075 |
| Molecular Weight: | 364 |
| NCBI Full Name: | Fructose-bisphosphate aldolase A |
| NCBI Synonym Full Names: | aldolase A, fructose-bisphosphate |
| NCBI Official Symbol: | ALDOA�� |
| NCBI Official Synonym Symbols: | ALDA; GSD12; HEL-S-87p�� |
| NCBI Protein Information: | fructose-bisphosphate aldolase A; muscle-type aldolase; lung cancer antigen NY-LU-1; fructose-1,6-bisphosphate triosephosphate-lyase; epididymis secretory sperm binding protein Li 87p |
| UniProt Protein Name: | Fructose-bisphosphate aldolase A |
| UniProt Synonym Protein Names: | Lung cancer antigen NY-LU-1; Muscle-type aldolase |
| Protein Family: | Fructose-bisphosphate aldolase |
| UniProt Gene Name: | ALDOA�� |
| UniProt Entry Name: | ALDOA_HUMAN |
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