Human C-Src Tyrosine Kinase Recombinant Protein (CPRT2490)

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CPRT2490
€278

Description

Data SheetMSDS

CSK Human Recombinant Protein

Name: CSK Human
Synonyms: Tyrosine-protein kinase CSK, C-Src kinase, Protein-tyrosine kinase CYL, CSK, C-Src Tyrosine Kinase.
Introduction: C–Src Tyrosine Kinase, also known as CSK, regulates cell growth, migration, differentiation, and immune response. CSK Phosphorylates tyrosine residues located in the C–terminal tails of Src–family kinases. CSK is a protein codinggene which suppresses signalingby several surface receptors. AmongCSK’s related pathways are PI–3K cascade and Signalingby FGFR.
Description: CSK Human Recombinant produced in E.coli is a single, non–glycosylated polypeptide chain containing 473 amino acids (1–450) and having a molecular mass of 53.1 kDa.The CSK is fused to a 23 amino acid His–tag at N–terminus and purified by proprietary chromatographic techniques.
Source: Escherichia Coli.
Pack size: 0
Physical Appearance: Sterile Filtered clear solution.
Formulation: CSK protein (0.5mg/ml) is containing Phosphate Buffered Saline (pH 7.4), 20% glycerol and 1mM DTT.
Solubility: N/A
Stability: Store at 4°C if entire vial will be used within 2–4 weeks. Store, frozen at –20°C for longer periods of time. For longterm storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze–thaw cycles.
Purity: Greater than 95.0% as determined by SDS–PAGE.
Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MGSMSAIQAA WPSGTECIAK YNFHGTAEQD LPFCKGDVLT IVAVTKDPNW YKAKNKVGRE GIIPANYVQK REGVKAGTKL SLMPWFHGKI TREQAERLLY PPETGLFLVR ESTNYPGDYT LCVSCDGKVE HYRIMYHASK LSIDEEVYFE NLMQLVEHYT SDADGLCTRL IKPKVMEGTV AAQDEFYRSgWALNMKELKL LQTIGKGEFgDVMLGDYRGN KVAVKCIKND ATAQAFLAEA SVMTQLRHSN LVQLLGVIVE EKGGLYIVTE YMAKGSLVDY LRSRGRSVLgGDCLLKFSLD VCEAMEYLEgNNFVHRDLAA RNVLVSEDNV AKVSDFGLTK EASSTQDTGK LPVKWTAPEA LREKKFSTKS DVWSFGILLW EIYSFGRVPY PRIPLKDVVP RVEKGYKMDA PDGCPPAVYE VMKNCWHLDA AMRPSFLQLR EQLEHIKTHE LHL.
Biological Activity: N/A
Usage: Assay Genie’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Uniprot: P41240

CSK Human Recombinant Protein - Protein Information

UniProt Protein Function: CSK: a tyrosine kinase of the Csk family that phosphorylates and inhibits Src family kinases. Specifically phosphorylates Y504 on LCK, which acts as a negative regulatory site. Csk and the phospho-tyrosine phosphatase CD45 reciprocally regulate phosphorylation of the inhibitory tyrosine of the Src family kinases Lck and Fyn during T-cell receptor mediated signaling during thymic development.
UniProt Protein Details:

Protein type:Protein kinase, tyrosine (non-receptor); EC 2.7.10.2; Protein kinase, TK; Kinase, protein; TK group; Csk family

Chromosomal Location of Human Ortholog: 15q24.1

Cellular Component: cytoplasm; cytosol; extrinsic to internal side of plasma membrane; plasma membrane

Molecular Function:identical protein binding; kinase activity; non-membrane spanning protein tyrosine kinase activity; protein binding; protein C-terminus binding; protein-tyrosine kinase activity; receptor binding

Biological Process: cell differentiation; cell migration; central nervous system development; epidermal growth factor receptor signaling pathway; innate immune response; negative regulation of Golgi to plasma membrane protein transport; protein amino acid phosphorylation; regulation of cell proliferation; regulation of cytokine production; T cell costimulation; T cell receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway

UniProt Code: P41240
NCBI GenInfo Identifier: 729887
NCBI Gene ID: 1445
NCBI Accession: P41240.1
UniProt Secondary Accession: P41240,Q2M3N2, Q6FGZ6,
UniProt Related Accession: P41240
Molecular Weight: 50,704 Da
NCBI Full Name: Tyrosine-protein kinase CSK
NCBI Synonym Full Names: c-src tyrosine kinase
NCBI Official Symbol: CSK  
NCBI Protein Information: tyrosine-protein kinase CSK
UniProt Protein Name: Tyrosine-protein kinase CSK
UniProt Synonym Protein Names: C-Src kinase; Protein-tyrosine kinase CYL
Protein Family: Chloroplast sensor kinase
UniProt Gene Name: CSK  
UniProt Entry Name: CSK_HUMAN
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Additional Information

Product type:
Recombinant Protein
Reactivity:
Human
Host Species:
E.Coli
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