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Human HTATIP2 Recombinant Protein (RPPB1836)

SKU:
RPPB1836
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9BUP3
Research Area:
Enzymes
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Description

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Product Name:Human HTATIP2 Recombinant Protein
Product Code:RPPB1836
Size:20µg
Species:Human
Target:HTATIP2
Synonyms:TIP30, CC3, SDR44U1, HTATIP2, EC=1.1.1.-, HIV-1 TAT-interactive protein 2, FLJ26963.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:HTATIP2 protein solution (1mg/ml) containing 20mM Tris-HCl pH-8, 1mM DTT & 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MAETEALSKL REDFRMQNKS VFILGASGET GRVLLKEILE QGLFSKVTLI GRRKLTFDEE AYKNVNQEVV DFEKLDDYAS AFQGHDVGFC CLGTTRGKAG AEGFVRVDRD YVLKSAELAK AGGCKHFNLL SSKGADKSSN FLYLQVKGEV EAKVEELKFD RYSVFRPGVL LCDRQESRPG EWLVRKFFGS LPDSWARGHS VPVVTVVRAM LNNVVRPRDK QMELLENKAI HDLGKAHGSL KP

HTATIP2 is part of the short-chain dehydrogenases/reductases (SDR) family which acts as a tumor suppressor in metabolic suppression, inhibition of angiogenesis and induces the expression of apoptosis related genes Bad and Siva. HTATIP2 cooperates with the activation domain of HIV-1 TAT and enhances its transcription by phosphorylating RNA polymerase II (Pol II). Defects in HTATIP2 are related with hepatocellular carcinomas and apoptotic resistant tumor cells, implicating a probable use for HTATIP2 in antitumor therapy.

HTATIP2 Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 262 amino acids (1-242 a.a.) and having a molecular mass of 29.3 kDa. The HTATIP2 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:HTATIP2: Oxidoreductase required for tumor suppression. NAPDH- bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Oxidoreductase; Apoptosis; Tumor suppressor; Nuclear envelope; Transcription factor; EC 1.1.1.-

Chromosomal Location of Human Ortholog: 11p15.1

Cellular Component: membrane; cytoplasm; nuclear envelope; nucleus

Molecular Function:protein binding; transcription coactivator activity; oxidoreductase activity

Biological Process: regulation of transcription from RNA polymerase II promoter; viral reproduction; apoptosis; nuclear import; angiogenesis; cell differentiation; regulation of angiogenesis; negative regulation of apoptosis

UniProt Code:Q9BUP3
NCBI GenInfo Identifier:317373366
NCBI Gene ID:10553
NCBI Accession:Q9BUP3.2
UniProt Secondary Accession:Q9BUP3,O15383, O60520, O95345, Q53GC1, Q53GG2, Q6IBI3 A8K7S7, D3DQY8,
UniProt Related Accession:Q9BUP3
Molecular Weight:242
NCBI Full Name:Oxidoreductase HTATIP2
NCBI Synonym Full Names:HIV-1 Tat interactive protein 2, 30kDa
NCBI Official Symbol:HTATIP2��
NCBI Official Synonym Symbols:CC3; TIP30; SDR44U1��
NCBI Protein Information:oxidoreductase HTATIP2; Tat-interacting protein (30kD); HIV-1 TAT-interactive protein 2; 30 kDa HIV-1 TAT-interacting protein; short chain dehydrogenase/reductase family 44U, member 1
UniProt Protein Name:Oxidoreductase HTATIP2
UniProt Synonym Protein Names:30 kDa HIV-1 TAT-interacting protein; HIV-1 TAT-interactive protein 2
Protein Family:Oxidoreductase
UniProt Gene Name:HTATIP2��
UniProt Entry Name:HTAI2_HUMAN

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