Human MECR Recombinant Protein (RPPB1934)
- SKU:
- RPPB1934
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9BV79
- Research Area:
- Enzymes
Description
| Product Name: | Human MECR Recombinant Protein |
| Product Code: | RPPB1934 |
| Size: | 10µg |
| Species: | Human |
| Target: | MECR |
| Synonyms: | NRBF1, CGI-63, FASN2B, EC 1.3.1.38, MECR, Mitochondrial Trans-2-Enoyl-CoA Reductase. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | MECR Human solution containing 20mM Trsi pH-8, 0.2M NaCl, 5mM DTT & 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MPAKVVELKN LELAAVRGSD VRVKMLAAPI NPSDINMIQG NYGLLPELPA VGGNEGVAQV VAVGSNVTGL KPGDWVIPAN AGLGTWRTEA VFSEEALIQV PSDIPLQSAA TLGVNPCTAY RMLMDFEQLQ PGDSVIQNAS NSGVGQAVIQ IAAALGLRTI NVVRDRPDIQ KLSDRLKSLG AEHVITEEEL RRPEMKNFFK DMPQPRLALN CVGGKSSTEL LRQLARGGTM VTYGGMAKQP VVASVSLLIF KDLKLRGFWL SQWKKDHSPD QFKELILTLC DLIRRGQLTA PACSQVPLQD YQSALEASMK PFISSKQILT M |
MECR catalyzes the reduction of trans-2-enoyl-CoA to acyl-CoA with chain length from C6 to C16 in an NADPH dependent manner with preference to medium chain length substrate. MECR protein takes part in the mitochondrial synthesis of fatty acids.
MECR Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 341 amino acids (54-373 a.a.) and having a molecular mass of 49.8 kDa. The MECR is fused to 21 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | MECR: Catalyzes the reduction of trans-2-enoyl-CoA to acyl-CoA with chain length from C6 to C16 in an NADPH-dependent manner with preference to medium chain length substrate. May have a role in the mitochondrial synthesis of fatty acids. Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Lipid Metabolism - fatty acid elongation in mitochondria; Oxidoreductase; EC 1.3.1.38 Chromosomal Location of Human Ortholog: 1p35.3 Cellular Component: mitochondrion; nucleus Molecular Function:zinc ion binding; trans-2-enoyl-CoA reductase (NADPH) activity Biological Process: fatty acid metabolic process; fatty acid biosynthetic process |
| UniProt Code: | Q9BV79 |
| NCBI GenInfo Identifier: | 334302832 |
| NCBI Gene ID: | 51102 |
| NCBI Accession: | Q9BV79.2 |
| UniProt Secondary Accession: | Q9BV79,Q5SYU0, Q5SYU1, Q5SYU2, Q6IBU9, Q9Y373, B3KT72 |
| UniProt Related Accession: | Q9BV79 |
| Molecular Weight: | 373 |
| NCBI Full Name: | Trans-2-enoyl-CoA reductase, mitochondrial |
| NCBI Synonym Full Names: | mitochondrial trans-2-enoyl-CoA reductase |
| NCBI Official Symbol: | MECR�� |
| NCBI Official Synonym Symbols: | NRBF1; CGI-63; FASN2B�� |
| NCBI Protein Information: | trans-2-enoyl-CoA reductase, mitochondrial; nuclear receptor binding factor 1; mitochondrial 2-enoyl thioester reductase; homolog of yeast 2-enoyl thioester reductase |
| UniProt Protein Name: | Trans-2-enoyl-CoA reductase, mitochondrial |
| UniProt Synonym Protein Names: | Nuclear receptor-binding factor 1; HsNrbf-1; NRBF-1 |
| UniProt Gene Name: | MECR�� |
| UniProt Entry Name: | MECR_HUMAN |
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