Description
| Product Name: | Human MFAP2 Recombinant Protein |
| Product Code: | RPPB3966 |
| Size: | 10µg |
| Species: | Human |
| Target: | MFAP2 |
| Synonyms: | Microfibrillar-associated protein 2, MFAP-2, Microfibril-associated glycoprotein 1, MAGP, MAGP-1, MFAP2, MAGP1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | MFAP2 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 1M Urea and 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMQGQYDL DPLPPFPDHV QYTHYSDQID NPDYYDYQEV TPRPSEEQFQ FQSQQQVQQE VIPAPTPEPG NAELEPTEPG PLDCREEQYP CTRLYSIHRP CKQCLNEVCF YSLRRVYVIN KEICVRTVCA HEELLRADLC RDKFSKCGVM ASSGLCQSVA ASCARSCGSC |
Microfibrillar-associated protein 2 (MFAP2) is an O-glycosylated protein discharged to the extracellular space and the extracellular matrix. MFAP2 connects with biglycan and elastin in a ternary complex. MFAP2 plays a key role in the support and distensibility of the juxtacanalicular region of these collector channels. MFAP2 inhibits LTB-1 binding to fibrillin-1, promotes the phosphorylation of Smad2 thus mediating the consequent extracellular deposition of latent TGFbeta.
MFAP2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 190 amino acids (18-183 a.a) and having a molecular mass of 21.5kDa.MFAP2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | MFAP2: Component of the elastin-associated microfibrils. Belongs to the MFAP family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 1p36.1-p35 Cellular Component: extracellular region; microfibril Biological Process: embryonic eye morphogenesis; extracellular matrix organization and biogenesis; post-embryonic eye morphogenesis |
| NCBI Summary: | Microfibrillar-associated protein 2 is a major antigen of elastin-associated microfibrils and a candidate for involvement in the etiology of inherited connective tissue diseases. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2008] |
| UniProt Code: | P55001 |
| NCBI GenInfo Identifier: | 1708914 |
| NCBI Gene ID: | 4237 |
| NCBI Accession: | P55001.1 |
| UniProt Secondary Accession: | P55001,Q53X60, Q5JXY0, |
| UniProt Related Accession: | P55001 |
| Molecular Weight: | 17,444 Da |
| NCBI Full Name: | Microfibrillar-associated protein 2 |
| NCBI Synonym Full Names: | microfibrillar associated protein 2 |
| NCBI Official Symbol: | MFAP2�� |
| NCBI Official Synonym Symbols: | MAGP; MAGP1; MAGP-1�� |
| NCBI Protein Information: | microfibrillar-associated protein 2 |
| UniProt Protein Name: | Microfibrillar-associated protein 2 |
| UniProt Synonym Protein Names: | Microfibril-associated glycoprotein 1; MAGP; MAGP-1 |
| Protein Family: | Microfibrillar-associated protein |
| UniProt Gene Name: | MFAP2�� |
| UniProt Entry Name: | MFAP2_HUMAN |
