Human Protein Kinase Akt1/PKB alpha Inactive Enzyme Recombinant Protein (CPRT2615)

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SKU:
CPRT2615
€1,736

Description

Data SheetMSDS

PKAkt1/PKBa Human Recombinant Protein

Name:PKAkt1/PKBa Human
Synonyms:RAC-alpha serine/threonine-protein kinase, EC 2.7.11.1, RAC-PK-alpha, Protein kinase B, PKB, C-AKT, AKT1, AKT, RAC, PRKBA, MGC99656, RAC-ALPHA.
Introduction:Akt1, also known as "Akt" or protein kinaseB (PKB) is an important molecule in mammaliancellular signaling.In humans, there are three genes in the "Akt family": Akt1, Akt2, and Akt3. These enzymesare members of the serine/threonine–specific protein kinasefamily (EC2.7.11.1).Akt1 is involved in cellular survival pathways, by inhibitingapoptoticprocesses. Akt1 is also able to induce protein synthesispathways, and is therefore a key signalingprotein in the cellular pathways that lead to skeletal muscle hypertrophy, and general tissue growth. Since it can block apoptosis, and thereby promote cell survival, Akt1 has been implicated as a major factor in many types of cancer. Akt (now also called Akt1) was originally identified as the oncogenein the transformingretrovirus, AKT8.
Description:PKAkt1 is a glycosilated polypeptide having a molecular mass of 59.1 kDa, fused with a polyhistidine tag at N–terminus (to facilitate removal of Akt1 kinase from the reaction mixture).Inactive enzyme, suitable for negative control experiments or for phosphorylation as a substrate.Recombinant Protein Kinase B is purified by proprietary chromatographic techniques.
Source:Sf9 insect cells.
Pack size:20µg
Physical Appearance:Sterile Filtered clear solution.
Formulation:PKAkt1 in 50mM Tris–HCl, 100mM NaCl, 1mM DTT, 25mM beta glycerophosphate, 50% glycerol, pH 8.5.
Solubility:N/A
Stability:Store at 4°C if entire vial will be used within 2–4 weeks. Store, frozen at –20°C for longer periods of time. Avoid multiple freeze–thaw cycles.
Purity:Greater than 90% as determined by SDS–PAGE.
Amino Acid Sequence:N/A
Biological Activity:No protease activity (Twinningtest). The Specific activity is 235 U/mg.
Usage:Assay Genie’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Uniprot:P31749
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Additional Information

Product type:
Recombinant Protein
Reactivity:
Human
Host Species:
Sf9, Insect cells
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