Human RELM b Recombinant Protein (RPPB0921)
- SKU:
- RPPB0921
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9BQ08
- Research Area:
- Cytokines
Description
| Product Name: | Human RELM b Recombinant Protein |
| Product Code: | RPPB0921 |
| Size: | 25µg |
| Species: | Human |
| Target: | RELM b |
| Synonyms: | Resistin-like beta, RELM beta, Cysteine-rich secreted protein FIZZ2, Colon and small intestine-specific cysteine-rich protein, Cysteine-rich secreted protein A12-alpha-like 1, Colon carcinoma-related gene protein, RELM-b, XCP2, HXCP2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Filtered and lyophilized from 0.5 mg/ml in 0.05M Acetate buffer pH-4. |
| Solubility: | Add 0.2 ml of 0.1M Acetate buffer pH-4 and let the lyophilized pellet dissolve completely. For conversion into higher pH value, we recommend intensive dilution by relevant buffer to a concentration of 10?g/ml. In higher concentrations the solubility of this antigen is limited. |
| Stability: | Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSTQCSLDS VMDKKIKDVL NSLEYSPSPI SKKLSCASVK SQGRPSSCPA GMAVTGCACG YGCGSWDVQLETTCHCQCSV VDWTTARCCH LTKLRSHHHH HH |
RELM-beta (Resistin-Like Molecule-beta) is a member of a recently identified family of secreted proteins containing a conserved cystein-rich C-terminus. The RELM family consists of resistin (also called FIZZ3), RELM-alfa (FIZZ1), RELM-beta (FIZZ2) and RELM-gamma. Only resisistin and RELM-beta were found in humans whereas all four RELM family members were identified in rodents.RELM-beta appears to be produced as a homodimer exclusively by intestinal goblet cells and can be found in high quantities in stool. Remarkably, stool of germ-free mice displaying sterile intestinal tract does not contain RELM-beta until bacterial colonization takes place after pathogen-free mice entered natural environment. Some, but not all, colon carcinoma cell lines secrete RELM-beta into the cell culture supernatant.The physiological function of RELM-beta is not known. High doses of recombinant RELM-beta showed hyperglycemic effects including lowered glucose disposal and increased hepatic glucose production in mice.
RELM-beta Human Recombinant is a His-Tagged Fusion Protein which is 11 kDa protein containing 90 amino acid residues of the RELM-beta human and 12 additional amino acid residues - HisTag (underlined).
| UniProt Protein Function: | resistin-like beta: Probable hormone. Belongs to the resistin/FIZZ family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 3q13.1 Cellular Component: cellular_component; extracellular region Molecular Function:hormone activity; molecular_function Biological Process: cell proliferation |
| UniProt Code: | Q9BQ08 |
| NCBI GenInfo Identifier: | 14211897 |
| NCBI Gene ID: | 84666 |
| NCBI Accession: | NP_115968.1 |
| UniProt Secondary Accession: | Q9BQ08,Q14D27, |
| UniProt Related Accession: | Q9BQ08 |
| Molecular Weight: | 11,730 Da |
| NCBI Full Name: | resistin-like beta |
| NCBI Synonym Full Names: | resistin like beta |
| NCBI Official Symbol: | RETNLB�� |
| NCBI Official Synonym Symbols: | XCP2; FIZZ1; FIZZ2; HXCP2; RELMb; RELMbeta; RELM-beta�� |
| NCBI Protein Information: | resistin-like beta; C/EBP-epsilon regulated myeloid-specific secreted cysteine-rich protein precursor 2; colon and small intestine-specific cysteine-rich protein; colon carcinoma-related gene protein; cysteine-rich secreted A12-alpha-like protein 1; cyste |
| UniProt Protein Name: | Resistin-like beta |
| UniProt Synonym Protein Names: | Colon and small intestine-specific cysteine-rich protein; Colon carcinoma-related gene protein; Cysteine-rich secreted protein A12-alpha-like 1; Cysteine-rich secreted protein FIZZ2; RELMbeta |
| Protein Family: | Resistin |
| UniProt Gene Name: | RETNLB�� |
| UniProt Entry Name: | RETNB_HUMAN |
