Human VAMP4 Recombinant Protein (RPPB5106)
- SKU:
- RPPB5106
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O75379
Description
| Product Name: | Human VAMP4 Recombinant Protein |
| Product Code: | RPPB5106 |
| Size: | 10µg |
| Species: | Human |
| Target: | VAMP4 |
| Synonyms: | Vesicle-associated membrane protein 4, VAMP-4, VAMP4, VAMP24. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The VAMP4 protein solution contains 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, and 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MPPKFKRHLN DDDVTGSVKS ERRNLLEDDS DEEEDFFLRG PSGPRFGPRN DKIKHVQNQV DEVIDVMQEN ITKVIERGER LDELQDKSES LSDNATAFSN RSKQLRRQMW WRGCKLEHHH HHH |
VAMP4 belongs to the synaptobrevin family who are involved in docking and/or fusion of vesicles with cell membrane. VAMP4 is enriched in the trans-Golgi network and may be a factor in the trans-Golgi network-to-endosome transport. VAMP4 is involved in the pathway which functions to eliminate an inhibitor (most likely synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. Synaptobrevins, syntaxins, and SNAP25 are the chief components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane.
VAMP4 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 123 amino acids (1-115 a.a.) and having a molecular mass of 14.5kDa.VAMP4 is fused to an 8 amino acids His Tag at C-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | VAMP4: Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule. Belongs to the synaptobrevin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Vesicle; Membrane protein, integral Chromosomal Location of Human Ortholog: 1q24-q25 Cellular Component: SNARE complex; Golgi membrane; Golgi apparatus; cell surface; lysosome; integral to membrane; trans-Golgi network; endosome Molecular Function:SNAP receptor activity; SNARE binding Biological Process: regulation of Golgi to plasma membrane protein transport; ER to Golgi vesicle-mediated transport; exocytosis; Golgi to plasma membrane protein transport; microtubule cytoskeleton organization and biogenesis |
| NCBI Summary: | Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. This protein may play a role in trans-Golgi network-to-endosome transport. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O75379 |
| NCBI GenInfo Identifier: | 20141854 |
| NCBI Gene ID: | 8674 |
| NCBI Accession: | O75379.2 |
| UniProt Related Accession: | O75379 |
| Molecular Weight: | Observed: 16KDPredicted: 17 kDa |
| NCBI Full Name: | Vesicle-associated membrane protein 4 |
| NCBI Synonym Full Names: | vesicle associated membrane protein 4 |
| NCBI Official Symbol: | VAMP4�� |
| NCBI Official Synonym Symbols: | VAMP-4; VAMP24�� |
| NCBI Protein Information: | vesicle-associated membrane protein 4 |
| UniProt Protein Name: | Vesicle-associated membrane protein 4 |
| Protein Family: | Vesicle-associated membrane protein |
| UniProt Gene Name: | VAMP4�� |
| UniProt Entry Name: | VAMP4_HUMAN |
