Human Zinc Finger Protein 346 Recombinant Protein (CPRT5185)

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CPRT5185
€278

Description

Recombinant Protein DatasheetAntibody MSDS

ZNF346 Human Recombinant Protein

Name:ZNF346 Human
Synonyms:Zinc finger protein 346, JAZ, Zfp346, ZNF346.
Introduction:ZNF346 is a nucleolar, zinc finger protein which specially binds to double–stranded RNA or RNA/DNA fusions, instead of DNA alone. Zinc finger domains vital for dsRNA bindingand essential for its nucleolar localization. ZNF346 takes part in cell growth and survival.
Description:ZNF346 Human Recombinant produced in E.coli is a single, non–glycosylated polypeptide chain containing 317 amino acids (1–294) and having a molecular mass of 35.3 kDa.ZNF346 is fused to a 23 amino acid His–tag at N–terminus & purified by proprietary chromatographic techniques.
Source:Escherichia Coli.
Pack size:20µg
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The ASCC1 solution (0.25mg/ml) contains 20mM Tris–HCl buffer (pH 8.0), 0.2M NaCl, 50% glycerol and 2mM DTT.
Solubility:N/A
Stability:Store at 4°C if entire vial will be used within 2–4 weeks. Store, frozen at –20°C for longer periods of time. For longterm storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze–thaw cycles.
Purity:Greater than 90.0% as determined by SDS–PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMEYPAPA TVQAADGGAA GPYSSSELLE GQEPDGVRFD RERARRLWEA VSGAQPVGRE EVEHMIQKNQ CLFTNTQCKV CCALLISESQ KLAHYQSKKH ANKVKRYLAI HGMETLKGET KKLDSDQKSS RSKDKNQCCP ICNMTFSSPV VAQSHYLGKT HAKNLKLKQQ STKVEALHQN REMIDPDKFC SLCHATFNDP VMAQQHYVGK KHRKQETKLK LMARYGRLAD PAVTDFPAGK GYPCKTCKIV LNSIEQYQAH VSGFKHKNQS PKTVASSLGQ IPMQRQPIQK DSTTLED.
Biological Activity:N/A
Usage:Assay Genie’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Uniprot:Q9UL40

ZNF346 Human Recombinant Protein - Protein Information

UniProt Protein Function:ZNF346: Binds to dsRNA and DNA. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Nucleolus

Chromosomal Location of Human Ortholog: 5q35.2

Cellular Component: nucleoplasm; cytoplasm; nucleolus; nucleus

Molecular Function:protein binding; enzyme binding; zinc ion binding; double-stranded RNA binding

Biological Process: positive regulation of apoptosis

NCBI Summary:The protein encoded by this gene is a nucleolar, zinc finger protein that preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are not only essential for dsRNA binding, but are also required for its nucleolar localization. The encoded protein may be involved in cell growth and survival. [provided by RefSeq, Jul 2008]
UniProt Code:Q9UL40
NCBI GenInfo Identifier:74735051
NCBI Gene ID:23567
NCBI Accession:Q9UL40.1
UniProt Secondary Accession:Q9UL40,Q68CV9, Q6ZMW1, B7Z367,
UniProt Related Accession:Q9UL40
Molecular Weight:294
NCBI Full Name:Zinc finger protein 346
NCBI Synonym Full Names:zinc finger protein 346
NCBI Official Symbol:ZNF346  
NCBI Official Synonym Symbols:JAZ; Zfp346  
NCBI Protein Information:zinc finger protein 346; just another zinc finger protein; double-stranded RNA-binding zinc finger protein JAZ
UniProt Protein Name:Zinc finger protein 346
UniProt Synonym Protein Names:Just another zinc finger protein
Protein Family:Zinc finger protein
UniProt Gene Name:ZNF346  
UniProt Entry Name:ZN346_HUMAN
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Additional Information

Product type:
Recombinant Protein
Reactivity:
Human
Host Species:
E.Coli
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