KIR2DS5 Antibody (PACO60020)
- SKU:
- PACO60020
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
KIR2DS5 Antibody (PACO60020)
The KIR2DS5 Polyclonal Antibody (PACO60020) is a vital tool for researchers studying KIR2DS5, a killer cell immunoglobulin-like receptor (KIR) involved in immune response modulation. This antibody, produced in rabbits, exhibits high reactivity to human samples and has been validated for use in Western blot applications. By specifically targeting the KIR2DS5 protein, this antibody allows for precise detection and analysis in various cell types, making it an invaluable asset for investigations in immunology and cancer research.
KIR2DS5 is a receptor with the potential to impact immune function by regulating the activity of natural killer cells. Its role in immune response modulation positions it as a key target for research on diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. Understanding the function of KIR2DS5 is crucial for developing therapeutic strategies that manipulate immune responses in these disease settings.
| Antibody Name: | KIR2DS5 Antibody (PACO60020) |
| Antibody SKU: | PACO60020 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Killer cell immunoglobulin-like receptor 2DS5 protein (162-242AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunofluorescence staining of HepG2 cells with PACO60020 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells. |
| Synonyms: | Killer cell immunoglobulin-like receptor 2DS5 (CD158 antigen-like family member G) (MHC class I NK cell receptor) (Natural killer-associated transcript 9) (NKAT-9) (CD antigen CD158g), KIR2DS5, CD158G NKAT9 |
| UniProt Protein Function: | KIR2DS5: Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells. Belongs to the immunoglobulin superfamily.Protein type: Membrane protein, integral; Receptor, misc.Chromosomal Location of Human Ortholog: 19q13.4Cellular Component: plasma membraneBiological Process: innate immune response |
| UniProt Protein Details: | |
| NCBI Summary: | Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q14953 |
| NCBI GenInfo Identifier: | 2833260 |
| NCBI Gene ID: | 3810 |
| NCBI Accession: | Q14953.1 |
| UniProt Secondary Accession: | Q14953 |
| UniProt Related Accession: | Q14953 |
| Molecular Weight: | 33,644 Da |
| NCBI Full Name: | Killer cell immunoglobulin-like receptor 2DS5 |
| NCBI Synonym Full Names: | killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 5 |
| NCBI Official Symbol: | KIR2DS5 |
| NCBI Official Synonym Symbols: | NKAT9; CD158G |
| NCBI Protein Information: | killer cell immunoglobulin-like receptor 2DS5 |
| UniProt Protein Name: | Killer cell immunoglobulin-like receptor 2DS5 |
| UniProt Synonym Protein Names: | CD158 antigen-like family member G; MHC class I NK cell receptor; Natural killer-associated transcript 9; NKAT-9; CD_antigen: CD158g |
| Protein Family: | Killer cell immunoglobulin-like receptor |
| UniProt Gene Name: | KIR2DS5 |
| UniProt Entry Name: |
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