The L2 Antibody (PACO34694) is a powerful tool for researchers studying L2, a protein involved in viral infection and cellular interactions. This antibody, produced by Assay Genie, is raised in rabbits and has been validated for use in various applications, including immunofluorescence and flow cytometry.L2 is a key player in the entry of certain viruses into host cells, making it a critical target for antiviral research. By binding specifically to the L2 protein, this antibody allows for the visualization and analysis of L2 expression in a wide range of cell types.
Its high reactivity with human samples makes it ideal for investigating viral infections and developing strategies to block viral entry.Researchers in virology, cell biology, and infectious disease will find the L2 Antibody (PACO34694) invaluable for their studies. Its specificity and sensitivity make it a reliable tool for exploring the mechanisms of viral infection and identifying potential targets for antiviral therapy. Unlock the secrets of viral entry with the L2 Antibody from Assay Genie.
Antibody Name:
L2 Antibody (PACO34694)
Antibody SKU:
PACO34694
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Human papillomavirus type 18
Immunogen:
Recombinant Human papillomavirus type 18 Minor capsid protein L2 protein (1-462AA)
Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers. Plays a role in capsid stabilization through interaction with the major capsid protein L1. Once the virion enters the host cell, escorts the genomic DNA into the nucleus, in particular by promoting virion endosomal escape. It is involved, through its interaction with host dynein, in the intracellular microtubule-dependent transport of viral capsid toward the nucleus. Mediates the viral genome import into the nucleus through binding to host importins. Mediates the viral genome import into the nucleus through binding to host importins. Once within the nucleus, L2 localizes viral genomes to PML bodies in order to activate early gene expression for establishment of infection. Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions. During virion assembly, encapsidates the genome by direct interaction with the viral DNA (By similarity).
Synonyms:
Minor capsid protein L2, L2
UniProt Protein Function:
Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers. Plays a role in capsid stabilization through interaction with the major capsid protein L1. Once the virion enters the host cell, L2 escorts the genomic DNA into the nucleus by promoting escape from the endosomal compartments and traffic through the host Golgi network. Plays a role through its interaction with host dynein in the intracellular microtubule-dependent transport of viral capsid toward the nucleus. Mediates the viral genome import into the nucleus through binding to host importins. Once within the nucleus, L2 localizes viral genomes to host PML bodies in order to activate early gene expression for establishment of infection. Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions. During virion assembly, encapsidates the genome by direct interaction with the viral DNA.
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