Description
| Product Name: | Human WWC1 Recombinant Protein |
| Product Code: | RPPB5153 |
| Size: | 20µg |
| Species: | Human |
| Target: | WWC1 |
| Synonyms: | WW and C2 domain containing 1, HBEBP3, HBEBP36, KIBRA, Protein KIBRA, HBeAg-binding protein 3, Kidney and brain protein, WW domain-containing protein 1, WWC1, KIAA0869. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The WWC1 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 20% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSEAVGATR IQIALKYDEK NKQFAILIIQ LSNLSALLQQ QDQKVNIRVA VLPCSESTTC LFRTRPLDAS DTLVFNEVFW VSMSYPALHQ KTLRVDVCTT DRSHLEECLG GAQISLAEVC RSGERSTRWY NL |
WW and C2 Domain Containing 1 (WWC1) is a cytoplasmic phosphoprotein which interacts with PRKC-zeta and dynein light chain-1. WWC1 takes part in cognition and memory performance. In some individuals, alleles of WWC1 have enhanced memory.
WWC1 Human Recombinant produced in E. coli is. a single polypeptide chain containing 152 amino acids (655-783) and having a molecular mass of 17kDa. WWC1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | KIBRA: a postsynaptic scaffolding protein associated with human memory performance. Interacts via its WW domains with the postsynaptic protein DDN, which plays a role in synaptic plasticity. Expressed in the hypothalamus and cerebellum, and in the hippocampus and cortex, both regions of the brain that are related to memory. Co-localizes with PKCZ in the mouse hippocampus. Binds to synaptopodin, modulating podocyte directional migration. Forms a complex with dynein light chain 1 that is recruited to ER-responsive promoters, and that is required for ER transactivation in breast cancer cells. Binds the minus end-directed microtubule motor dynein. Its amino terminus binds the eight PDZ domain of the polarity protein INADL. Two human isoforms have been described. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 5q34 Cellular Component: cytoplasm; cytosol; nucleus; perinuclear region of cytoplasm Molecular Function:kinase binding; protein binding; protein complex scaffold; transcription coactivator activity Biological Process: cell migration; establishment of cell polarity; negative regulation of organ growth; negative regulation of transcription from RNA polymerase II promoter; positive regulation of MAPKKK cascade; regulation of intracellular transport Disease: Memory Quantitative Trait Locus |
| NCBI Summary: | The protein encoded by this gene is a cytoplasmic phosphoprotein that interacts with PRKC-zeta and dynein light chain-1. Alleles of this gene have been found that enhance memory in some individuals. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] |
| UniProt Code: | Q8IX03 |
| NCBI GenInfo Identifier: | 74714457 |
| NCBI Gene ID: | 23286 |
| NCBI Accession: | Q8IX03.1 |
| UniProt Secondary Accession: | Q8IX03,O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29 B4DK05, |
| UniProt Related Accession: | Q8IX03 |
| Molecular Weight: | 125,905 Da |
| NCBI Full Name: | Protein KIBRA |
| NCBI Synonym Full Names: | WW and C2 domain containing 1 |
| NCBI Official Symbol: | WWC1�� |
| NCBI Official Synonym Symbols: | KIBRA; HBEBP3; HBEBP36; MEMRYQTL; PPP1R168�� |
| NCBI Protein Information: | protein KIBRA |
| UniProt Protein Name: | Protein KIBRA |
| UniProt Synonym Protein Names: | HBeAg-binding protein 3; Kidney and brain protein; KIBRA; WW domain-containing protein 1 |
| UniProt Gene Name: | WWC1�� |
| UniProt Entry Name: | KIBRA_HUMAN |
