Anti-MAOA Antibody (RACO0557)
- SKU:
- RACO0557
- Product type:
- Recombinant Antibody
- Reactivity:
- Human
- Host Species:
- Human
- Isotype:
- IgG
- Application:
- IF
- Application:
- ELISA
- Application:
- IHC
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Product Name: | MAOA Antibody |
| Product SKU: | RACO0557 |
| Size: | 50ul |
| Host Species: | Homo sapiens (Human) |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | IHC:1:50-1:200, IF:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | A synthesized peptide derived from human Monoamine Oxidase A |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | Affinity-chromatography |
| Clonality: | Monoclonal |
| Isotype: | Rabbit IgG |
| Conjugate: | Non-conjugated |
| Background: | Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine. |
| Synonyms: | Amine oxidase [flavin-containing] A (EC 1.4.3.4) (Monoamine oxidase type A) (MAO-A), MAOA |
 | IHC image of RACO0557 diluted at 1:100 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. |
 | Immunofluorescence staining of HepG2 Cells with RACO0557 at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L). |
 | IHC image of RACO0557 diluted at 1:100 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. |
| UniProt Protein Function: | MAOA: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine. Defects in MAOA are the cause of Brunner syndrome (BRUNS). Brunner syndrome is a form of X-linked non- dysmorphic mild mental retardation. Male patients are affected by a syndrome of borderline mental retardation and exhibit abnormal behavior, including disturbed regulation of impulsive aggression. Obligate female carriers have normal intelligence and behavior. Belongs to the flavin monoamine oxidase family. |
| UniProt Protein Details: | Protein type:EC 1.4.3.4; Membrane protein, integral; Amino Acid Metabolism - tryptophan; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Amino Acid Metabolism - histidine; Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - glycine, serine and threonine; Oxidoreductase; Amino Acid Metabolism - tyrosine Chromosomal Location of Human Ortholog: Xp11.3 Cellular Component: mitochondrial outer membrane; mitochondrion; integral to membrane Molecular Function:amine oxidase activity Biological Process: synaptic transmission; biogenic amine metabolic process; neurotransmitter catabolic process; dopamine catabolic process; xenobiotic metabolic process; neurotransmitter secretion; neurotransmitter biosynthetic process Disease: Brunner Syndrome |
| NCBI Summary: | This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012] |
| UniProt Code: | P21397 |
| NCBI GenInfo Identifier: | 113978 |
| NCBI Gene ID: | 4128 |
| NCBI Accession: | P21397.1 |
| UniProt Secondary Accession: | P21397,Q16426, B4DF46, |
| UniProt Related Accession: | P21397 |
| Molecular Weight: | 527 |
| NCBI Full Name: | Amine oxidase |
| NCBI Synonym Full Names: | monoamine oxidase A |
| NCBI Official Symbol: | MAOA |
| NCBI Official Synonym Symbols: | MAO-A |
| NCBI Protein Information: | amine oxidase [flavin-containing] A; amine oxidase [flavin-containing] A; monoamine oxidase type A |
| UniProt Protein Name: | Amine oxidase [flavin-containing] A |
| UniProt Synonym Protein Names: | Monoamine oxidase type A; MAO-A |
| Protein Family: | Amine oxidase |
| UniProt Gene Name: | MAOA |
| UniProt Entry Name: | AOFA_HUMAN |
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