The ORF3 Antibody (PAC035150) is a valuable tool for researchers studying the ORF3 protein, a key component of certain viruses. This polyclonal antibody, raised in rabbits, is highly specific and reactive with samples from various species, making it suitable for a wide range of applications. Validated for use in Western blot and immunohistochemistry, this antibody detects the ORF3 protein, allowing for detailed analysis and characterization in different cell types and tissues.The ORF3 protein is known to play a crucial role in viral replication and pathogenesis, making it a target of interest for virology and infectious disease research.
By understanding the function and expression of the ORF3 protein, researchers can gain insights into the mechanisms of viral infection and potential therapeutic interventions. This antibody is a valuable tool for studying the role of the ORF3 protein in viral biology, host-pathogen interactions, and antiviral drug development.
Antibody Name:
ORF3 Antibody (PACO35150)
Antibody SKU:
PACO35150
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Hepatitis E virus genotype 1
Immunogen:
Recombinant Hepatitis E virus genotype 1 Protein ORF3 protein (1-114AA)
Plays critical roles in the final steps of viral release by interacting with host TSG101, a member of the vacuolar protein-sorting pathway and using other cellular host proteins involved in vesicle formation pathway. Acts also as a viroporin and forms ion conductive pores allowing viral particle release. Impairs the generation of type I interferon by downregulating host TLR3 and TLR7 as well as their downstream signaling pathways.
Synonyms:
Protein ORF3 (pORF3), ORF3
UniProt Protein Function:
May act as a viral regulatory protein involved in the modulation of mitogenic signaling pathways. May be involved in virion morphogenesis and viral pathogenesis. Expedites the processing and secretion of AMBP from the hepatocyte.
