PAX7 Antibody (PACO43298)
- SKU:
- PACO43298
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | PAX7 Antibody (PACO43298) |
| Antibody SKU: | PACO43298 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:200-1:1000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Paired box protein Pax-7 protein (276-505AA) |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: PAX7 antibody at 4µg/ml + 293T whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 56, 57 kDa. Observed band size: 56 kDa. |
 | Immunohistochemistry of paraffin-embedded human lung cancer using PACO43298 at dilution of 1:100. |
| Background: | Transcription factor playing a role in myogenesis through regulation of muscle precursor cells proliferation. |
| Synonyms: | Paired box protein Pax-7 (HuP1), PAX7, HUP1 |
| UniProt Protein Function: | PAX7: Probable transcription factor. May have a role in myogenesis. Defects in PAX7 are a cause of rhabdomyosarcoma type 2 (RMS2). It is a form of rhabdomyosarcoma, a highly malignant tumor of striated muscle derived from primitive mesenchimal cells and exhibiting differentiation along rhabdomyoblastic lines. Rhabdomyosarcoma is one of the most frequently occurring soft tissue sarcomas and the most common in children. It occurs in four forms: alveolar, pleomorphic, embryonal and botryoidal rhabdomyosarcomas. A chromosomal aberration involving PAX7 is found in rhabdomyosarcoma. Translocation t(1;13)(p36;q14) with FOXO1. The resulting protein is a transcriptional activator. Belongs to the paired homeobox family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA-binding; Oncoprotein; Transcription factor Chromosomal Location of Human Ortholog: 1p36.13 Molecular Function:transcription factor activity Biological Process: anatomical structure morphogenesis; negative regulation of apoptosis Disease: Rhabdomyosarcoma 2 |
| NCBI Summary: | This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box 7 gene is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008] |
| UniProt Code: | P23759 |
| NCBI GenInfo Identifier: | 857434982 |
| NCBI Gene ID: | 5081 |
| NCBI Accession: | P23759.4 |
| UniProt Secondary Accession: | P23759,Q0VA99, Q2PJS5, E9PFV9, |
| UniProt Related Accession: | P23759 |
| Molecular Weight: | 55kDa |
| NCBI Full Name: | Paired box protein Pax-7 |
| NCBI Synonym Full Names: | paired box 7 |
| NCBI Official Symbol: | PAX7 |
| NCBI Official Synonym Symbols: | HUP1; RMS2; PAX7B |
| NCBI Protein Information: | paired box protein Pax-7 |
| UniProt Protein Name: | Paired box protein Pax-7 |
| UniProt Synonym Protein Names: | HuP1 |
| Protein Family: | Paired box protein |
| UniProt Gene Name: | PAX7 |
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