The PIK3C2A Polyclonal Antibody is a high-quality antibody designed for research involving the PIK3C2A protein, a key player in the PI3K/Akt signaling pathway. This antibody, raised in rabbits, is highly specific for detecting PIK3C2A in human samples and is validated for use in Western blot applications. By binding to the PIK3C2A protein, researchers can accurately detect and analyze its expression in various cell types, making it an essential tool for studies in cell signaling, cancer biology, and drug development.The PIK3C2A protein, a member of the phosphoinositide 3-kinase (PI3K) family, is known for its role in regulating cell growth, proliferation, and survival.
Dysregulation of the PI3K/Akt pathway, in which PIK3C2A is involved, has been linked to various diseases, including cancer, diabetes, and cardiovascular disorders. As such, understanding the function of PIK3C2A is crucial for developing targeted therapies and personalized medicine approaches in these areas.This PIK3C2A Polyclonal Antibody provides researchers with a reliable tool for studying the expression and activity of PIK3C2A in different experimental settings. Its high specificity and sensitivity make it an ideal choice for investigating the molecular mechanisms underlying PIK3C2A function and its potential as a therapeutic target in various diseases.
Product Name:
PIK3C2A Polyclonal Antibody
SKU:
CAB21543
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human PIK3C2A (NP_002636.2).
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling.
Purification Method:
Affinity purification
Gene ID:
5286
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using PIK3C2A Rabbit pAb (CAB21543) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
