The R9AP/RGS9BP Polyclonal Antibody is a valuable tool for researchers studying R9AP (RGS9BP), a key protein involved in the regulation of signal transduction in the visual system. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to R9AP/RGS9BP, the antibody enables researchers to detect and analyze this important protein in a variety of cell types.R9AP/RGS9BP is essential for the proper functioning of photoreceptor cells in the retina, playing a crucial role in the visual signal transduction cascade. Dysregulation of R9AP/RGS9BP has been implicated in various retinal diseases and vision disorders, making it an attractive target for further research in ophthalmology and vision science.
By elucidating the function of R9AP/RGS9BP, researchers can gain insights into the mechanisms underlying these conditions and potentially identify novel therapeutic targets. Overall, the R9AP/RGS9BP Polyclonal Antibody offers researchers a reliable tool for investigating the role of R9AP/RGS9BP in visual signal transduction and its implications for retinal health and disease. Its specificity and sensitivity make it an essential reagent for studies aiming to deepen our understanding of the molecular mechanisms governing vision.
Product Name:
R9AP/RGS9BP Polyclonal Antibody
SKU:
CAB22557
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant Protein corresponding to a sequence within amino acids 1-107 of human R9AP/RGS9BP(NP_997274.2).
Sequence:
MARE ECKA LLDG LNKT TACY HHLV LTVG GSAD SQNL RQEL QKTR QKAQ ELAV STCA RLTA VLRD RGLA ADER AEFE RLWV AFSG CLDL LEAD MRRA LELG AAFP LHA
Tested Applications:
WBELISA
Recommended Dilution:
WB,1:100 - 1:500
Synonyms:
R9AP; RGS9; PERRS; R9AP/RGS9BP
Positive Sample:
293T cells transfected with R9AP/RGS9BP
Conjugate:
Unconjugated
Cellular Localization:
neuron projection
Calculated MW:
25kDa
Observed MW:
30kDa
The protein encoded by this gene functions as a regulator of G protein-coupled receptor signaling in phototransduction. Studies in bovine and mouse show that this gene is expressed only in the retina, and is localized in the rod outer segment membranes. This protein is associated with a heterotetrameric complex, specifically interacting with the regulator of G-protein signaling 9, and appears to function as the membrane anchor for the other largely soluble interacting partners. Mutations in this gene are associated with prolonged electroretinal response suppression (PERRS), also known as bradyopsia.
Purification Method:
Affinity purification
Gene ID:
388531
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and 293T cells transfected with R9AP/RGS9BP using R9AP/RGS9BP Rabbit pAb (CAB22557) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection:ECL Basic Kit (AbGn00020).Exposure time: 15s.
