Endothelial protein C receptor (EPCR); also known as activated protein C receptor (APC receptor) or PROCR; is a receptor for Protein C. Protein C plays an important role in many metabolism processes in humans and other animals after activated by binding to Endothelial protein C receptor (EPCR). Because of the EPCR is found primarily on endothelial cells (cells on the inside of blood vessels); activated protein C is found maily near endothelial cells. Protein C is pleiotropic; with two main functions: anticoagulation and cytoprotection. Which function will be performed depend on whether or not protein C remains bind to EPCR after activated. The anticoagulation occurs when it does not. In this case; protein C functions as an anticoagulant by irreversibly proteolytically inactivating Factor Va and Factor VIIIa; turning them into Factor Vi and Factor VIIIi respectively. When still bound to EPCR; activated protein C performs its cytoprotective effects; acting on the effector substrate PAR-1; protease-activated receptor-1. To a degree; APC's anticoagulant properties are independent of its cytoprotective ones; in that expression of one pathway is not affected by the existence of the other.
Human EPCR Recombinant Protein (RPES0288)
Endothelial Protein C Receptor, Activated Protein C Receptor, APC Receptor, Endothelial Cell Protein C Receptor, CD201, PROCR, EPCR
Met 1-Thr 209
<1.0 EU per µg of the protein as determined by the LAL method.
A DNA sequence encoding the extracellular domain of human PROCR (Q9UNN8) (Met 1-Thr 209); was fused with a polyhistidine tag at the C-terminus.
> 97 % as determined by reducing SDS-PAGE.
Lyophilized from sterile PBS; pH 7.4
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.