Recombinant Human FABP6/I-BABP Protein (His Tag) (RPES2775)

SKU:
RPES2775
€361

Description

ELISA Kit Technical Manual

Recombinant Human FABP6/I-BABP Protein (His Tag)

Background:Fatty Acid-Binding Protein 6 (FABP6) is cytoplasmic protein that binds long-chain fatty acids and other hydrophobic ligands which belongs to the calycin superfamily. FABP6 expression is restricted in the small intestine to the ileum where it is involved in the enterohepatic circulation of bile acids. FABP6 forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior. Isoform 2 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at protein level). Isoform 1 is expressed in the jejunum, ileum, cecum and ascending colon intestine. FABP6 plays a role in fatty acid uptake, transport, and metabolism. FABP6 stimulates gastric acid and pepsinogen secretion. It seems to be able to bind to bile salts and bilirubins.
Name:Recombinant Human FABP6/I-BABP Protein (His Tag)
Size:10µg
Assay Genie SKU:RPES2775
Synonyms:Gastrotropin; GT; Fatty Acid-Binding Protein 6; Ileal Lipid-Binding Protein; ILBP; Intestinal 15 kDa Protein; I5P; Intestinal Bile Acid-Binding Protein; I-BABP; FABP6; ILBP; ILLBP
Species:Human
Expression host:E.coli
Sequence:Met1-Ala128
Accession:P51161
Mol Mass:16.6 kDa
AP Mol Mass:15 kDa
Tag:N-His
Purity:> 95% as determined by reducing SDS-PAGE.
Endotoxin:< 1.0 EU per ?g as determined by the LAL method.
Storage:Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping:This product is provided as liquid. It is shipped at frozen temperature with blue ice.Upon receipt, store it immediately at<-20°C.
Formulation:Supplied as a 0.2 um filtered solution of 20mM TrisHCl, 0.5mM DTT, 50% Glycerol, pH 8.0.
Reconstitution:Please refer to the printed manual for detailed information.
UniProt Protein Function:FABP6: Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. 2 isoforms of the human protein are produced by alternative promoter.
UniProt Protein Details:

Protein type:Lipid-binding

Chromosomal Location of Human Ortholog: 5q33.3-q34

Cellular Component: cytoplasm; cytosol

Molecular Function:transporter activity; lipid binding

Biological Process: bile acid and bile salt transport; negative regulation of cell proliferation; bile acid metabolic process; lipid metabolic process; transmembrane transport

NCBI Summary:This gene encodes the ileal fatty acid binding protein. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP6 and FABP1 (the liver fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. Transcript variants generated by alternate transcription promoters and/or alternate splicing have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P51161
NCBI GenInfo Identifier:1708457
NCBI Gene ID:2172
NCBI Accession:P51161.2
UniProt Secondary Accession:P51161,Q07DR7, Q8TBI3, Q9UGI7,
UniProt Related Accession:P51161
Molecular Weight:128
NCBI Full Name:Gastrotropin
NCBI Synonym Full Names:fatty acid binding protein 6, ileal
NCBI Official Symbol:FABP6
NCBI Official Synonym Symbols:ILBP; I5P; I-BAP; ILBP3; ILLBP; I-BABP; I-BALB
NCBI Protein Information:gastrotropin; GT; intestinal 15 kDa protein; ileal lipid-binding protein; illeal lipid-binding protein; ileal bile acid binding protein
UniProt Protein Name:Gastrotropin
UniProt Synonym Protein Names:Fatty acid-binding protein 6; Ileal lipid-binding protein; ILBP; Intestinal 15 kDa protein; I5P; Intestinal bile acid-binding protein; I-BABP
Protein Family:Gastrotropin
UniProt Gene Name:FABP6
UniProt Entry Name:FABP6_HUMAN
View AllClose

Additional Information

Product type:
Recombinant Protein
Host species:
E.coli
Reactivity:
Human
View AllClose