Human I 309 Recombinant Protein (RPPB1160)
- SKU:
- RPPB1160
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P22362
- Research Area:
- Chemokines
Description
| Product Name: | Human I 309 Recombinant Protein |
| Product Code: | RPPB1160 |
| Size: | 10µg |
| Species: | Human |
| Target: | I 309 |
| Synonyms: | Small inducible cytokine A1, CCL1, T lymphocyte-secreted protein I-309, chemokine (C-C motif) ligand 1, P500, SISe, TCA3, I-309, SCYA1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | The CCL1 protein was lyophilized with no additives. |
| Solubility: | It is recommended to reconstitute the lyophilized I-309 in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized I-309 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL1 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 99.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | The sequence of the first five N-terminal amino acids was determined and was found to be Ser-Lys-Ser-Met-Gln |
| Biological Activity: | The Biological activity is calculated by its ability to chemoattract human T cells at 10-100ng/ml corresponding to a Specific Activity of 10,000-100,000IU/mg. |
Chemokine (C-C motif) ligand 1 (CCL1) is a small glycoprotein secreted by activated T cells that belongs to a family inflammatory cytokines known as chemokines. CCL1 attracts monocytes, NK cells, and immature B cells and dendritic cells by interacting with a cell surface chemokine receptor called CCR8. This chemokine resides in a large cluster of CC chemokines on human chromosome 17.
I-309 Human Recombinant produced in E.Coli is a single,non-glycosylated, polypeptide chain containing 74 amino acids and having a molecular mass of 8504 Dalton. The I-309 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CCL1: Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8. Belongs to the intercrine beta (chemokine CC) family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide; Chemokine; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 17q12 Cellular Component: extracellular space Molecular Function:chemokine activity Biological Process: cellular calcium ion homeostasis; viral reproduction; immune response; chemotaxis; signal transduction |
| NCBI Summary: | This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, is secreted by activated T cells and displays chemotactic activity for monocytes but not for neutrophils. It binds to the chemokine (C-C motif) receptor 8. [provided by RefSeq, Sep 2014] |
| UniProt Code: | P22362 |
| NCBI GenInfo Identifier: | 123950 |
| NCBI Gene ID: | 6346 |
| NCBI Accession: | P22362.1 |
| UniProt Secondary Accession: | P22362,Q2M309, B2R5G9, |
| UniProt Related Accession: | P22362 |
| Molecular Weight: | 10,992 Da |
| NCBI Full Name: | C-C motif chemokine 1 |
| NCBI Synonym Full Names: | chemokine (C-C motif) ligand 1 |
| NCBI Official Symbol: | CCL1�� |
| NCBI Official Synonym Symbols: | P500; SISe; TCA3; I-309; SCYA1�� |
| NCBI Protein Information: | C-C motif chemokine 1; inflammatory cytokine I-309; T lymphocyte-secreted protein I-309; small inducible cytokine A1 (I-309, homologous to mouse Tca-3) |
| UniProt Protein Name: | C-C motif chemokine 1 |
| UniProt Synonym Protein Names: | Small-inducible cytokine A1; T lymphocyte-secreted protein I-309 |
| Protein Family: | Cyclin |
| UniProt Gene Name: | CCL1�� |
| UniProt Entry Name: | CCL1_HUMAN |
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