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Human PLA2G16 Recombinant Protein (RPES0096)

SKU:
RPES0096
Product type:
Recombinant Protein
Host species:
E.coli
Reactivity:
Human
€303

Description

ELISA Kit Technical Manual

Recombinant Human PLA2G16 Protein (His Tag)

Background:Group XVI Phospholipase A1/A2 (PLA2G16) belongs to the H-rev 107 family. PLA2G16 is expressed in a number of human tumors including ovarian carcinomas, lung carcinomas. PLA2G16 is involved in the regulation of differentiation and survival. PLA2G16 regulates adipocyte lipolysis and release of fatty acids through a G-protein coupled pathway involving prostaglandin and EP3. It has also been reported to play a crucial role in the development of obesity in mouse models.
Name:Recombinant Human PLA2G16 Protein (His Tag)
Size:10µg
Assay Genie SKU:RPES0096
Synonyms:Group XVI Phospholipase A1/A2; Adipose-Specific Phospholipase A2; AdPLA; H-Rev 107 Protein Homolog; HRAS-Like Suppressor 1; HRAS-Like Suppressor 3; HRSL3; HREV107; HREV107-3; Renal Carcinoma Antigen NY-REN-65; PLA2G16; HRASLS3; HREV107
Species:Human
Expression host:E.coli
Sequence:Asp12-Asp132
Accession:P53816
Mol Mass:15.9 kDa
AP Mol Mass:15 kDa
Tag:N-6His
Purity:> 95 % as determined by reducing SDS-PAGE.
Endotoxin:< 1.0 EU per µg as determined by the LAL method.
Storage:Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping:This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C.
Formulation:Supplied as a 0.2 um filtered solution of 20mM TrisHCl, pH 8.0.
Reconstitution:Please refer to the printed manual for detailed information.
UniProt Protein Function:PLA2G16: Exhibits PLA1/2 activity, catalyzing the calcium- independent hydrolysis of acyl groups in various phosphotidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. Specifically catalyzes the release of fatty acids from phospholipids in adipose tissue. N- and O- acylation activity is hardly detectable. Might decrease protein phosphatase 2A (PP2A) activity. Belongs to the H-rev107 family.
UniProt Protein Details:

Protein type:EC 3.1.1.4; EC 3.1.1.32; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q12.3

Cellular Component: perinuclear region of cytoplasm; endoplasmic reticulum; integral to membrane; cytosol

Molecular Function:phospholipase A2 activity; protein binding; phospholipase A1 activity

Biological Process: phospholipid metabolic process; glycerophospholipid biosynthetic process; lipid catabolic process; negative regulation of cell cycle

UniProt Code:P53816
NCBI GenInfo Identifier:75517991
NCBI Gene ID:11145
NCBI Accession:
UniProt Related Accession:P53816,Q3MI98
Molecular Weight:21,441 Da
NCBI Full Name:PLA2G16 protein
NCBI Synonym Full Names:phospholipase A2, group XVI
NCBI Official Symbol:PLA2G16  
NCBI Official Synonym Symbols:AdPLA; HRSL3; HRASLS3; HREV107; HREV107; HREV107-3; MGC118754; H-REV107  
NCBI Protein Information:group XVI phospholipase A2; OTTHUMP00000237069; adipose-specific PLA2; HRAS-like suppressor 1; HRAS-like suppressor 3; H-rev 107 protein homolog; Ca-independent phospholipase A1/2; adipose-specific phospholipase A2; renal carcinoma antigen NY-REN-65
UniProt Protein Name:PLA2G16 protein
Protein Family:HRAS-like suppressor
UniProt Gene Name:PLA2G16  
UniProt Entry Name:Q3MI98_HUMAN