Recombinant Human Secretogranin-2/SCG2 Protein (His Tag) (RPES4088)



ELISA Kit Technical Manual

Recombinant Human Secretogranin-2/SCG2 Protein (His Tag)

Background:Secretogranin-2 is also known as Chromogranin-C,Secretogranin II, SgII. In humans, it is encoded by the SCG2 gene.It belongs to the chromogranin/secretogranin protein family. Secretogranin-2 is a neuroendocrine secretory granule protein, which is the precursor for biologically active peptides. It derived secretoneurin was distributed with strong immunoreactivity in the somata of pelvic ganglion neurons,72% of which also contained tyrosine hydroxyldse,as well as in nerve terminals in the muscular layer and the lamina propria of the vas deferens.
Name:Recombinant Human Secretogranin-2/SCG2 Protein (His Tag)
Assay Genie SKU:RPES4088
Synonyms:Secretogranin-2;Chromogranin-C;Secretogranin II; SgII.
Expression host:Human Cells
Mol Mass:68.8 kDa
AP Mol Mass:94 kDa
Purity:> 90 % as determined by reducing SDS-PAGE.
Endotoxin:< 1.0 EU per µg as determined by the LAL method.
Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8? for 2-7 days. Aliquots of reconstituted samples are stable at < -20'C for 3 months.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Formulation:Lyophilized from a 0.2 um filtered solution of 20mM PB,150mM NaCl, pH 7.4.
Reconstitution:Please refer to the printed manual for detailed information.
UniProt Protein Function:SCG2: Secretogranin-2 is a neuroendocrine secretory granule protein, which is the precursor for biologically active peptides. Belongs to the chromogranin/secretogranin protein family.
UniProt Protein Details:

Protein type:Cell cycle regulation; Motility/polarity/chemotaxis; Secreted; Cytokine; Secreted, signal peptide; Apoptosis

Chromosomal Location of Human Ortholog: 2q35-q36

Cellular Component: extracellular space

Molecular Function:chemoattractant activity; cytokine activity; protein binding

Biological Process: angiogenesis; endothelial cell migration; eosinophil chemotaxis; induction of positive chemotaxis; inflammatory response; MAPKKK cascade; negative regulation of endothelial cell proliferation; positive chemotaxis; positive regulation of endothelial cell proliferation; protein secretion

NCBI Summary:The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown. [provided by RefSeq, Jul 2008]
UniProt Code:P13521
NCBI GenInfo Identifier:143811457
NCBI Gene ID:7857
NCBI Accession:P13521.2
UniProt Secondary Accession:P13521,Q53T11, Q8TBH3, B2R662,
UniProt Related Accession:P13521
Molecular Weight:70,941 Da
NCBI Full Name:Secretogranin-2
NCBI Synonym Full Names:secretogranin II
NCBI Official Symbol:SCG2
NCBI Official Synonym Symbols:SN; CHGC; EM66; SgII
NCBI Protein Information:secretogranin-2
UniProt Protein Name:Secretogranin-2
UniProt Synonym Protein Names:Chromogranin-C; Secretogranin II; SgII
Protein Family:Secretogranin
UniProt Gene Name:SCG2
UniProt Entry Name:SCG2_HUMAN
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Additional Information

Product type:
Recombinant Protein
Host species:
Human Cells
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